Technology Process of 6,8-dichloro-4-o-tolyl-1,3-dihydronaphtho[2,3-c]furan
There total 5 articles about 6,8-dichloro-4-o-tolyl-1,3-dihydronaphtho[2,3-c]furan which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trifluorormethanesulfonic acid;
In
acetonitrile;
at 20 ℃;
regioselective reaction;
DOI:10.1016/j.tet.2021.132214
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / 0.5 h
1.2: 20 °C
2.1: silver hexafluoroantimonate; gold(III) chloride / dichloromethane / 1.67 h / 20 °C / Molecular sieve
With
gold(III) chloride; silver hexafluoroantimonate; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine;
In
dichloromethane;
1.1: Sonogashira coupling / 1.2: Sonogashira coupling;
DOI:10.1021/jo201918d
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
1.2: 2 h / 0 - 20 °C
2.1: copper(II) bis(trifluoromethanesulfonate) / dichloromethane / 0.5 h / 20 °C
3.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / 0.5 h
3.2: 20 °C
4.1: silver hexafluoroantimonate; gold(III) chloride / dichloromethane / 1.67 h / 20 °C / Molecular sieve
With
gold(III) chloride; silver hexafluoroantimonate; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); copper(II) bis(trifluoromethanesulfonate); sodium hydride; triethylamine;
In
tetrahydrofuran; dichloromethane; mineral oil;
2.1: Meinwald rearrangement / 3.1: Sonogashira coupling / 3.2: Sonogashira coupling;
DOI:10.1021/jo201918d
