8-<(carbobenzoxy-phenylalanyl)alanylamino>-6-methoxyquinoline

Base Information

• Chemical Name: 8-<(carbobenzoxy-phenylalanyl)alanylamino>-6-methoxyquinoline
• CAS No.: 102096-38-8
• Molecular Formula: C₃₀H₃₀N₄O₅
• Molecular Weight: 526.592
• Mol file: 102096-38-8.mol

Synonyms:8-<(carbobenzoxy-phenylalanyl)alanylamino>-6-methoxyquinoline

Chemical Property of 8-<(carbobenzoxy-phenylalanyl)alanylamino>-6-methoxyquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 8-<(carbobenzoxy-phenylalanyl)alanylamino>-6-methoxyquinoline

There total 1 articles about 8-<(carbobenzoxy-phenylalanyl)alanylamino>-6-methoxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-methoxyquinolin-8-amine (90-52-8) + N-benzyloxycarbonyl-L-phenylalanyl-L-alanine (3338-39-4,16088-00-9,16088-38-3,17563-25-6,55387-02-5,80996-16-3,21881-18-5) → 8-<(carbobenzoxy-phenylalanyl)alanylamino>-6-methoxyquinoline (102096-38-8)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; Yield given. Multistep reaction; 1.) ethyl acetate, DMF, 0 deg C, 5 min, 2) ethyl acetate, DMF, a) O deg C, 1h, b) room temperature, overnight;

Reference yield:

8-<(carbobenzoxy-phenylalanyl)alanylamino>-6-methoxyquinoline (102096-38-8) → (S)-N1-[(S)-2-(6-Methoxy-quinolin-8-ylamino)-1-methyl-ethyl]-3-phenyl-propane-1,2-diamine; hydrochloride (102096-43-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / HBr / acetic acid / Ambient temperature

2: 68 percent / 1.) LAH, 2) HCl / 1.) THF, reflux, 2) ether

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen bromide; In acetic acid;

upstream raw materials:

6-methoxyquinolin-8-amine

N-benzyloxycarbonyl-L-phenylalanyl-L-alanine

Downstream raw materials:

(S)-N¹-[(S)-2-(6-Methoxy-quinolin-8-ylamino)-1-methyl-ethyl]-3-phenyl-propane-1,2-diamine; hydrochloride