Toluene-4-sulfonic acid 3-(8-amino-1,4-dioxa-spiro[4.5]dec-8-yl)-2-(tert-butyl-dimethyl-silanyloxy)-propyl ester

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Chemical Name:Toluene-4-sulfonic acid 3-(8-amino-1,4-dioxa-spiro[4.5]dec-8-yl)-2-(tert-butyl-dimethyl-silanyloxy)-propyl ester
CAS No.:211430-43-2
Molecular Formula:C₂₄H₄₁NO₆SSi
Molecular Weight:499.744
Hs Code.:

Synonyms:Toluene-4-sulfonic acid 3-(8-amino-1,4-dioxa-spiro[4.5]dec-8-yl)-2-(tert-butyl-dimethyl-silanyloxy)-propyl ester

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Chemical Property of Toluene-4-sulfonic acid 3-(8-amino-1,4-dioxa-spiro[4.5]dec-8-yl)-2-(tert-butyl-dimethyl-silanyloxy)-propyl ester

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Technology Process of Toluene-4-sulfonic acid 3-(8-amino-1,4-dioxa-spiro[4.5]dec-8-yl)-2-(tert-butyl-dimethyl-silanyloxy)-propyl ester

There total 7 articles about Toluene-4-sulfonic acid 3-(8-amino-1,4-dioxa-spiro[4.5]dec-8-yl)-2-(tert-butyl-dimethyl-silanyloxy)-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 211430-42-1
8-(2'-tert-butyldimethylsilyloxy-3'-tosyloxypropyl)-8-phenylmethoxycarbonylamino-1,4-dioxaspiro[4.5]decane

: 211430-43-2
Toluene-4-sulfonic acid 3-(8-amino-1,4-dioxa-spiro[4.5]dec-8-yl)-2-(tert-butyl-dimethyl-silanyloxy)-propyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1016/S0040-4039(98)00797-7

Reference yield:

: 66500-55-8
cyclohexanone-4-carboxylic acid ethyleneacetal

: 211430-43-2
Toluene-4-sulfonic acid 3-(8-amino-1,4-dioxa-spiro[4.5]dec-8-yl)-2-(tert-butyl-dimethyl-silanyloxy)-propyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: diisopropylamine; BuLi / tetrahydrofuran; hexane / 1 h / 20 °C

1.2: 78 percent / tetrahydrofuran; hexane / 2 h / 20 °C

2.1: diphenylphosphoryl azide; triethylamine / benzene / 0.5 h / Heating

2.2: 65 percent / benzene / 5 h / Heating

3.1: 94 percent / osmium tetroxide; N-methylmorpholine N-oxide / acetone; H₂O; 2-methyl-propan-2-ol / 5 h / 20 °C

4.1: 86 percent / 4-(N,N-dimethylamino)pyridine / pyridine / 4 h / 20 °C

5.1: 92 percent / imidazole / dimethylformamide / 4.5 h / 20 °C

6.1: H₂ / 5 percent Pd/C / methanol / 3 h

With 1H-imidazole; dmap; osmium(VIII) oxide; n-butyllithium; diphenylphosphoranyl azide; hydrogen; 4-methylmorpholine N-oxide; triethylamine; diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; hexane; water; N,N-dimethyl-formamide; acetone; tert-butyl alcohol; benzene;
DOI:10.1016/S0040-4020(02)00436-2

Reference yield:

: 159638-73-0
8-(2'-propenyl)-1,4-dioxaspiro[4.5]decane-8-carboxylic acid

: 211430-43-2
Toluene-4-sulfonic acid 3-(8-amino-1,4-dioxa-spiro[4.5]dec-8-yl)-2-(tert-butyl-dimethyl-silanyloxy)-propyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: diphenylphosphoryl azide; triethylamine / benzene / 0.5 h / Heating

1.2: 65 percent / benzene / 5 h / Heating

2.1: 94 percent / osmium tetroxide; N-methylmorpholine N-oxide / acetone; H₂O; 2-methyl-propan-2-ol / 5 h / 20 °C

3.1: 86 percent / 4-(N,N-dimethylamino)pyridine / pyridine / 4 h / 20 °C

4.1: 92 percent / imidazole / dimethylformamide / 4.5 h / 20 °C

5.1: H₂ / 5 percent Pd/C / methanol / 3 h

With 1H-imidazole; dmap; osmium(VIII) oxide; diphenylphosphoranyl azide; hydrogen; 4-methylmorpholine N-oxide; triethylamine; palladium on activated charcoal; In pyridine; methanol; water; N,N-dimethyl-formamide; acetone; tert-butyl alcohol; benzene;
DOI:10.1016/S0040-4020(02)00436-2