(E)-3-(3-((5-((E)-2-carboxyvinyl)-3-(1H-tetrazol-5-yl)thiophen-2-yl)methyl)phenyl)acrylic acid

Base Information

Chemical Name:(E)-3-(3-((5-((E)-2-carboxyvinyl)-3-(1H-tetrazol-5-yl)thiophen-2-yl)methyl)phenyl)acrylic acid
CAS No.:1073314-21-2
Molecular Formula:C₁₈H₁₄N₄O₄S
Molecular Weight:382.4
Hs Code.:

Synonyms:(E)-3-(3-((5-((E)-2-carboxyvinyl)-3-(1H-tetrazol-5-yl)thiophen-2-yl)methyl)phenyl)acrylic acid

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Chemical Property of (E)-3-(3-((5-((E)-2-carboxyvinyl)-3-(1H-tetrazol-5-yl)thiophen-2-yl)methyl)phenyl)acrylic acid

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Technology Process of (E)-3-(3-((5-((E)-2-carboxyvinyl)-3-(1H-tetrazol-5-yl)thiophen-2-yl)methyl)phenyl)acrylic acid

There total 7 articles about (E)-3-(3-((5-((E)-2-carboxyvinyl)-3-(1H-tetrazol-5-yl)thiophen-2-yl)methyl)phenyl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (E)-methyl 3-(3-((3-(2-benzhydryl-2H-tetrazol-5-yl)-5-((E)-3-methoxy-3-oxoprop-1-enyl)thiophen-2-yl)methyl)phenyl)acrylate

: 1073314-21-2
(E)-3-(3-((5-((E)-2-carboxyvinyl)-3-(1H-tetrazol-5-yl)thiophen-2-yl)methyl)phenyl)acrylic acid

Guidance literature:: (E)-methyl 3-(3-((3-(2-benzhydryl-2H-tetrazol-5-yl)-5-((E)-3-methoxy-3-oxoprop-1-enyl)thiophen-2-yl)methyl)phenyl)acrylate; With lithium hydroxide; water; In methanol;

With trifluoroacetic acid; In dichloromethane; methoxybenzene;

Reference yield:

: 59918-86-4
5-(thiophen-3-yl)-1H-tetrazole

: 1073314-21-2
(E)-3-(3-((5-((E)-2-carboxyvinyl)-3-(1H-tetrazol-5-yl)thiophen-2-yl)methyl)phenyl)acrylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide; acetic acid / N,N-dimethyl-formamide / 20 °C

2.1: toluene-4-sulfonic acid / toluene / Heating / reflux

3.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / Cooling with ice-salt bath

3.2: 2 h / 20 - 40 °C

4.1: iodine; silver sulfate / 20 °C

5.1: 1,3-bis-(diphenylphosphino)propane; triethylamine / palladium diacetate / N,N-dimethyl-formamide / 12 h / 120 °C

6.1: lithium hydroxide; water / methanol

With lithium hydroxide; N-Bromosuccinimide; 1,3-bis-(diphenylphosphino)propane; water; iodine; isopropylmagnesium chloride; toluene-4-sulfonic acid; silver sulfate; acetic acid; triethylamine; palladium diacetate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene; 5.1: Heck Reaction;

Reference yield:

: 1641-09-4
3-thiophenecarbonitrile

: 1073314-21-2
(E)-3-(3-((5-((E)-2-carboxyvinyl)-3-(1H-tetrazol-5-yl)thiophen-2-yl)methyl)phenyl)acrylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium azide; zinc dibromide / N,N-dimethyl-formamide / 5 h / Heating / reflux

2.1: N-Bromosuccinimide; acetic acid / N,N-dimethyl-formamide / 20 °C

3.1: toluene-4-sulfonic acid / toluene / Heating / reflux

4.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / Cooling with ice-salt bath

4.2: 2 h / 20 - 40 °C

5.1: iodine; silver sulfate / 20 °C

6.1: 1,3-bis-(diphenylphosphino)propane; triethylamine / palladium diacetate / N,N-dimethyl-formamide / 12 h / 120 °C

7.1: lithium hydroxide; water / methanol

With lithium hydroxide; N-Bromosuccinimide; sodium azide; 1,3-bis-(diphenylphosphino)propane; water; iodine; isopropylmagnesium chloride; toluene-4-sulfonic acid; silver sulfate; acetic acid; triethylamine; zinc dibromide; palladium diacetate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene; 6.1: Heck Reaction;