2-[2-(2-chloro-6-methylamino-purin-9-yl)-ethyl]-propane-1,3-bisoxy(dibenzylphosphate)

Base Information

Chemical Name:2-[2-(2-chloro-6-methylamino-purin-9-yl)-ethyl]-propane-1,3-bisoxy(dibenzylphosphate)
CAS No.:1027657-72-2
Molecular Formula:C₃₉H₄₂ClN₅O₈P₂
Molecular Weight:806.192
Hs Code.:

Synonyms:2-[2-(2-chloro-6-methylamino-purin-9-yl)-ethyl]-propane-1,3-bisoxy(dibenzylphosphate)

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Chemical Property of 2-[2-(2-chloro-6-methylamino-purin-9-yl)-ethyl]-propane-1,3-bisoxy(dibenzylphosphate)

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Technology Process of 2-[2-(2-chloro-6-methylamino-purin-9-yl)-ethyl]-propane-1,3-bisoxy(dibenzylphosphate)

There total 5 articles about 2-[2-(2-chloro-6-methylamino-purin-9-yl)-ethyl]-propane-1,3-bisoxy(dibenzylphosphate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 990-91-0
dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

: 1027064-85-2
2-chloro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-6-methylamino-purine

: 1027657-72-2
2-[2-(2-chloro-6-methylamino-purin-9-yl)-ethyl]-propane-1,3-bisoxy(dibenzylphosphate)

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 25 ℃; for 13h;
DOI:10.1021/jm9905211

Reference yield:

: 71170-82-6
triethyl 3-bromopropane-1,1,1-tricarboxylate

: 1027657-72-2
2-[2-(2-chloro-6-methylamino-purin-9-yl)-ethyl]-propane-1,3-bisoxy(dibenzylphosphate)

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃ / dimethylformamide / 24 h / 60 °C

2: 50 percent / methanol / 3 h

3: 93 percent / NaBH₄ / CH₂Cl₂; methanol / 4 h / 25 °C

4: 78 percent / lithium diisopropylamide / tetrahydrofuran / 13 h / -78 - 25 °C

With sodium tetrahydroborate; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 1: Alkylation / 2: Decarboxylation / 3: Reduction / 4: phosphorylation;
DOI:10.1021/jm9905211

Reference yield:

: 82499-02-3
2-chloro-6-(N-methylamino)-9H-purine

: 1027657-72-2
2-[2-(2-chloro-6-methylamino-purin-9-yl)-ethyl]-propane-1,3-bisoxy(dibenzylphosphate)

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃ / dimethylformamide / 24 h / 60 °C

2: 50 percent / methanol / 3 h

3: 93 percent / NaBH₄ / CH₂Cl₂; methanol / 4 h / 25 °C

4: 78 percent / lithium diisopropylamide / tetrahydrofuran / 13 h / -78 - 25 °C

With sodium tetrahydroborate; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 1: Alkylation / 2: Decarboxylation / 3: Reduction / 4: phosphorylation;
DOI:10.1021/jm9905211