4-(2-(alaninocarbonyl)ethyl)tetradecachlorotriphenylmethyl radical ethyl ester

Base Information

• Chemical Name: 4-(2-(alaninocarbonyl)ethyl)tetradecachlorotriphenylmethyl radical ethyl ester
• CAS No.: 101981-10-6
• Molecular Formula: C₂₇H₁₄Cl₁₄NO₃
• Molecular Weight: 896.755
• Mol file: 101981-10-6.mol

Synonyms:4-(2-(alaninocarbonyl)ethyl)tetradecachlorotriphenylmethyl radical ethyl ester

Chemical Property of 4-(2-(alaninocarbonyl)ethyl)tetradecachlorotriphenylmethyl radical ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-(alaninocarbonyl)ethyl)tetradecachlorotriphenylmethyl radical ethyl ester

There total 11 articles about 4-(2-(alaninocarbonyl)ethyl)tetradecachlorotriphenylmethyl radical ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

(S)-alanine ethyl ester hydrochloride (1115-59-9) + tetradecachloro-4-(2-(chlorocarbonyl)ethyl)triphenylmethyl radical (101981-09-3) → 4-(2-(alaninocarbonyl)ethyl)tetradecachlorotriphenylmethyl radical ethyl ester (101981-10-6)

Guidance literature:

With triethylamine; In dichloromethane; for 1h; Ambient temperature;

DOI:10.1021/jo00363a013

Reference yield:

6,6’-((2,3,5,6-tetrachloro-4-methylphenyl)methylene)bis(1,2,3,4,5-pentachlorobenzene) (79839-38-6) → 4-(2-(alaninocarbonyl)ethyl)tetradecachlorotriphenylmethyl radical ethyl ester (101981-10-6)

Guidance literature:

Multi-step reaction with 9 steps

1: 95 percent / Br₂ / CCl₄ / 5 h / Irradiation

2: 82 percent / acetic acid / 72 h / Heating

3: 85 percent / aq. concd HCl / dioxane / 21 h / Heating

4: 87 percent / aq. NaOH / dioxane / 35 h / Ambient temperature

5: 83 percent / K₂CO₃ / dioxane / 20 h / Heating

6: 83 percent / aq. concd HCl / dioxane / 48 h / Heating

7: 1.) NaOH, 2.) I₂ / 1.) ethyl ether, DMSO, 24 h, 2.) ethyl ether, DMSO, 20 h

8: 85 percent / SOCl₂ / 17 h / Heating

9: 64 percent / triethylamine / CH₂Cl₂ / 1 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; thionyl chloride; bromine; iodine; potassium carbonate; triethylamine; In 1,4-dioxane; tetrachloromethane; dichloromethane; acetic acid;

DOI:10.1021/jo00363a013

Reference yield:

6,6'-((4-(bromomethyl)-2,3,5,6-tetrachlorophenyl)methylene)bis(1,2,3,4,5-pentachlorobenzene) (101998-20-3) → 4-(2-(alaninocarbonyl)ethyl)tetradecachlorotriphenylmethyl radical ethyl ester (101981-10-6)

Guidance literature:

Multi-step reaction with 8 steps

1: 82 percent / acetic acid / 72 h / Heating

2: 85 percent / aq. concd HCl / dioxane / 21 h / Heating

3: 87 percent / aq. NaOH / dioxane / 35 h / Ambient temperature

4: 83 percent / K₂CO₃ / dioxane / 20 h / Heating

5: 83 percent / aq. concd HCl / dioxane / 48 h / Heating

6: 1.) NaOH, 2.) I₂ / 1.) ethyl ether, DMSO, 24 h, 2.) ethyl ether, DMSO, 20 h

7: 85 percent / SOCl₂ / 17 h / Heating

8: 64 percent / triethylamine / CH₂Cl₂ / 1 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; thionyl chloride; iodine; potassium carbonate; triethylamine; In 1,4-dioxane; dichloromethane; acetic acid;

DOI:10.1021/jo00363a013

upstream raw materials:

(S)-alanine ethyl ester hydrochloride

tetradecachloro-4-(2-(chlorocarbonyl)ethyl)triphenylmethyl radical

6,6’-((2,3,5,6-tetrachloro-4-methylphenyl)methylene)bis(1,2,3,4,5-pentachlorobenzene)

4-(bromomethyl)tetradecachlorotriphenylmethyl radical