N-(N-benzyloxycarbonyl-D-phenylalanyl)-p-bis(2-chloroethyl)amino-L-phenylalanine benzyl ester

Base Information

Chemical Name:N-(N-benzyloxycarbonyl-D-phenylalanyl)-p-bis(2-chloroethyl)amino-L-phenylalanine benzyl ester
CAS No.:223431-93-4
Molecular Formula:C₃₇H₃₉Cl₂N₃O₅
Molecular Weight:676.64
Hs Code.:

Synonyms:N-(N-benzyloxycarbonyl-D-phenylalanyl)-p-bis(2-chloroethyl)amino-L-phenylalanine benzyl ester

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Chemical Property of N-(N-benzyloxycarbonyl-D-phenylalanyl)-p-bis(2-chloroethyl)amino-L-phenylalanine benzyl ester

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Technology Process of N-(N-benzyloxycarbonyl-D-phenylalanyl)-p-bis(2-chloroethyl)amino-L-phenylalanine benzyl ester

There total 5 articles about N-(N-benzyloxycarbonyl-D-phenylalanyl)-p-bis(2-chloroethyl)amino-L-phenylalanine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 223431-85-4
N-(N-benzyloxycarbonyl-D-phenylalanyl)-p-bis(2-hydroxyethyl)amino-L-phenylalanine benzyl ester

: 223431-93-4
N-(N-benzyloxycarbonyl-D-phenylalanyl)-p-bis(2-chloroethyl)amino-L-phenylalanine benzyl ester

Guidance literature:: With thionyl chloride; In chloroform; 1) room temperature, 1 h, 2) 40-45 deg C, 2 h;
DOI:10.1016/S0040-4020(98)01139-9

Reference yield:

: 127977-25-7
benzyl 2(S)-<(tert-butoxycarbonyl)amino>-3-(4'-nitrophenyl)propionate

: 223431-93-4
N-(N-benzyloxycarbonyl-D-phenylalanyl)-p-bis(2-chloroethyl)amino-L-phenylalanine benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 76 percent / N₂H₄*H₂O, graphite / dioxane / 105 °C

2: H₂O; acetic acid / 24 h / Ambient temperature

3: 4 M HCl / H₂O; dioxane / 2 h

4: 2.40 g / dioxane

5: 82 percent / SOCl₂ / CHCl₃ / 1) room temperature, 1 h, 2) 40-45 deg C, 2 h

With hydrogenchloride; thionyl chloride; pyrographite; hydrazine hydrate; In 1,4-dioxane; chloroform; water; acetic acid;
DOI:10.1016/S0040-4020(98)01139-9

Reference yield:

: p-nitro-L-phenylalanine benzyl ester toluene-p-sulfonate

: 223431-93-4
N-(N-benzyloxycarbonyl-D-phenylalanyl)-p-bis(2-chloroethyl)amino-L-phenylalanine benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / NaHCO₃, NaCl / CHCl₃; H₂O / 2 h / Heating

2: 76 percent / N₂H₄*H₂O, graphite / dioxane / 105 °C

3: H₂O; acetic acid / 24 h / Ambient temperature

4: 4 M HCl / H₂O; dioxane / 2 h

5: 2.40 g / dioxane

6: 82 percent / SOCl₂ / CHCl₃ / 1) room temperature, 1 h, 2) 40-45 deg C, 2 h

With hydrogenchloride; thionyl chloride; sodium hydrogencarbonate; pyrographite; hydrazine hydrate; sodium chloride; In 1,4-dioxane; chloroform; water; acetic acid;
DOI:10.1016/S0040-4020(98)01139-9