benzyl (2S,3R,4S,5R,6R)-3-difluoromethyl-3-methyl-7-oxo-6-phenoxyacetamido-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate-4-oxide

Base Information

Chemical Name:benzyl (2S,3R,4S,5R,6R)-3-difluoromethyl-3-methyl-7-oxo-6-phenoxyacetamido-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate-4-oxide
CAS No.:115252-99-8
Molecular Formula:C₂₃H₂₂F₂N₂O₆S
Molecular Weight:492.5
Hs Code.:

Synonyms:benzyl (2S,3R,4S,5R,6R)-3-difluoromethyl-3-methyl-7-oxo-6-phenoxyacetamido-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate-4-oxide

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Chemical Property of benzyl (2S,3R,4S,5R,6R)-3-difluoromethyl-3-methyl-7-oxo-6-phenoxyacetamido-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate-4-oxide

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Technology Process of benzyl (2S,3R,4S,5R,6R)-3-difluoromethyl-3-methyl-7-oxo-6-phenoxyacetamido-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate-4-oxide

There total 6 articles about benzyl (2S,3R,4S,5R,6R)-3-difluoromethyl-3-methyl-7-oxo-6-phenoxyacetamido-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate-4-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 115234-86-1
benzyl (2S,3R,5R,6R)-3-difluoromethyl-3-methyl-7-oxo-6-phenoxyacetamido-1-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

: 115234-88-3
benzyl (2S,3R,5R,6R)-3-difluoromethyl-3-methyl-7-oxo-6-phenoxyacetamido-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate-4,4-dioxide

: 115252-99-8
benzyl (2S,3R,4S,5R,6R)-3-difluoromethyl-3-methyl-7-oxo-6-phenoxyacetamido-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate-4-oxide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 1.25h; Ambient temperature;
DOI:10.1016/S0040-4020(01)90038-9

Reference yield: 25.0%

: 115234-86-1
benzyl (2S,3R,5R,6R)-3-difluoromethyl-3-methyl-7-oxo-6-phenoxyacetamido-1-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

: 115252-99-8
benzyl (2S,3R,4S,5R,6R)-3-difluoromethyl-3-methyl-7-oxo-6-phenoxyacetamido-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate-4-oxide

: 115253-00-4
benzyl (2S,3R,4R,5R,6R)-3-difluoromethyl-3-methyl-7-oxo-6-phenoxyacetamido-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate-4-oxide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 0.25h; Ambient temperature;
DOI:10.1016/S0040-4020(01)90038-9

Reference yield:

: 115234-74-7
benzyl (2S,3R,5R,6R)-3-formyl-3-methyl-7-oxo-6-phenoxyacetamido-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

: 115252-99-8
benzyl (2S,3R,4S,5R,6R)-3-difluoromethyl-3-methyl-7-oxo-6-phenoxyacetamido-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate-4-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / diethylaminosulfur trifluoride / CH₂Cl₂ / 0.5 h / Ambient temperature

2: 27 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 1.25 h / Ambient temperature

With diethylamino-sulfur trifluoride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1016/S0040-4020(01)90038-9