tert-butyl [3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-carbamoyl)-5-(pentafluoro-λ⁶-sulphanyl)phenyl]acetate

Base Information

• Chemical Name: tert-butyl [3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-carbamoyl)-5-(pentafluoro-λ⁶-sulphanyl)phenyl]acetate
• CAS No.: 1448316-83-3
• Molecular Formula: C₃₁H₃₀F₅N₅O₃S
• Molecular Weight: 647.669

Synonyms:tert-butyl [3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-carbamoyl)-5-(pentafluoro-λ⁶-sulphanyl)phenyl]acetate

Chemical Property of tert-butyl [3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-carbamoyl)-5-(pentafluoro-λ⁶-sulphanyl)phenyl]acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl [3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-carbamoyl)-5-(pentafluoro-λ⁶-sulphanyl)phenyl]acetate

There total 9 articles about tert-butyl [3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-carbamoyl)-5-(pentafluoro-λ⁶-sulphanyl)phenyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

3-(2-tert-butoxy-2-oxoethyl)-5-(pentafluoro-λ6-sulphanyl)benzoic acid (1448318-95-3) + 2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]aniline (1448317-39-2) → tert-butyl [3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-carbamoyl)-5-(pentafluoro-λ6-sulphanyl)phenyl]acetate (1448316-83-3)

Guidance literature:

With dmap; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

nicotinoylacetonitrile (30510-18-0) → tert-butyl [3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-carbamoyl)-5-(pentafluoro-λ6-sulphanyl)phenyl]acetate (1448316-83-3)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrogenchloride / ethanol; water / 4 h / Reflux

2: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate; caesium carbonate / 1,4-dioxane / 1 h / 140 °C / Inert atmosphere; Microwave irradiation

3: sulfuric acid / ethanol / 0.25 h / 130 °C / Microwave irradiation

4: palladium 10% on activated carbon; ammonium formate / ethanol; water / 2.5 h / Reflux

5: HATU; dmap / N,N-dimethyl-formamide / 3 h / 20 °C

With hydrogenchloride; dmap; sulfuric acid; palladium 10% on activated carbon; ammonium formate; palladium diacetate; caesium carbonate; HATU; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

1-(2,2-diethoxyethyl)-3-(pyridin-3-yl)-1H-pyrazole-5-amine (222056-48-6) → tert-butyl [3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-carbamoyl)-5-(pentafluoro-λ6-sulphanyl)phenyl]acetate (1448316-83-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate; caesium carbonate / 1,4-dioxane / 1 h / 140 °C / Inert atmosphere; Microwave irradiation

2: sulfuric acid / ethanol / 0.25 h / 130 °C / Microwave irradiation

3: palladium 10% on activated carbon; ammonium formate / ethanol; water / 2.5 h / Reflux

4: HATU; dmap / N,N-dimethyl-formamide / 3 h / 20 °C

With dmap; sulfuric acid; palladium 10% on activated carbon; ammonium formate; palladium diacetate; caesium carbonate; HATU; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;

upstream raw materials:

nicotinoylacetonitrile

1-(2,2-diethoxyethyl)-3-(pyridin-3-yl)-1H-pyrazole-5-amine

1-(2,2-diethoxyethyl)-N-(2,4-dimethyl-5-nitrophenyl)-3-(pyridin-3-yl)-1H-pyrazole-5-amine

1-(2,4-dimethyl-5-nitrophenyl)-6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazole

Downstream raw materials:

[3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}carbamoyl)-5-(pentafluoro-λ⁶-sulphanyl)phenyl]acetic acid

3-(2-amino-2-oxoethyl)-N-{2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]-phenyl}-5-(pentafluoro-λ⁶-sulphanyl)benzamide

N-{2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-3-(2-hydroxy-2-methylpropyl)-5-(pentafluoro-λ⁶-sulphanyl)benzamide

methyl [3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}carbamoyl)-5-(pentafluoro-λ⁶-sulphanyl)phenyl]acetate

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