Cyclopenta[b]pyrrol-2(1H)-one, hexahydro-, (3aR,6aS)-rel- (9CI)

Base Information

• Chemical Name: Cyclopenta[b]pyrrol-2(1H)-one, hexahydro-, (3aR,6aS)-rel- (9CI)
• CAS No.: 214263-63-5
• Molecular Formula: C₇H₁₁NO
• Molecular Weight: 125.17
• Mol file: 214263-63-5.mol

Synonyms:Cyclopenta[b]pyrrol-2(1H)-one, hexahydro-, (3aR,6aS)-rel- (9CI)

Chemical Property of Cyclopenta[b]pyrrol-2(1H)-one, hexahydro-, (3aR,6aS)-rel- (9CI)

Chemical Property:

• PSA: 29.10000
• LogP: 1.00380

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of Cyclopenta[b]pyrrol-2(1H)-one, hexahydro-, (3aR,6aS)-rel- (9CI)

There total 40 articles about Cyclopenta[b]pyrrol-2(1H)-one, hexahydro-, (3aR,6aS)-rel- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

N-[{3,5-bis(trifluoromethyl)benzoyl}oxy]-2-cyclopentylacetamide → 2-Oxo-cis-cyclopentanopyrrolidine (72845-14-8,214263-63-5)

Guidance literature:

With C₂₂H₂₆ClIrN₂O₃; potassium carbonate; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; In 2,2,2-trifluoroethanol; at 40 ℃; for 12h; diastereoselective reaction; Sealed tube;

DOI:10.1021/acs.orglett.9b00791

Reference yield: 75.0%

((1R,2R)-2-Amino-cyclopentyl)-acetic acid ethyl ester; hydrochloride (125355-92-2) → (-)-(R)-hexahydro-cyclopenta[b]pyrrol-2-one (131348-75-9,214263-63-5)

Guidance literature:

With sodium hydroxide; for 2h; Heating; or conc. NH₃;

DOI:10.1002/ardp.19903231109

Reference yield: 75.0%

((1S,2S)-2-Amino-cyclopentyl)-acetic acid ethyl ester; hydrochloride (125355-93-3) → (1S,5S)-2-azabicyclo<3.3.0>octan-3-one (131348-76-0,214263-63-5)

Guidance literature:

With sodium hydroxide; for 2h; Heating; or conc. NH₃;

DOI:10.1002/ardp.19903231109

upstream raw materials:

cis-hexahydro-2H-cyclopenta[b]furan-2-one

(2-hydroxyiminocyclopentyl)acetic acid ethyl ester

2-cyclopentylacetic acid

2-cyclopentylacetyl chloride

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