(2'S,3S)-3-benzoyloxy-N-(2-hydroxy-2-phenylethyl)pyrrolidine

Base Information

• Chemical Name: (2'S,3S)-3-benzoyloxy-N-(2-hydroxy-2-phenylethyl)pyrrolidine
• CAS No.: 259184-51-5
• Molecular Formula: C₁₉H₂₁NO₃
• Molecular Weight: 311.381
• Mol file: 259184-51-5.mol

Synonyms:(2'S,3S)-3-benzoyloxy-N-(2-hydroxy-2-phenylethyl)pyrrolidine

Chemical Property of (2'S,3S)-3-benzoyloxy-N-(2-hydroxy-2-phenylethyl)pyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2'S,3S)-3-benzoyloxy-N-(2-hydroxy-2-phenylethyl)pyrrolidine

There total 1 articles about (2'S,3S)-3-benzoyloxy-N-(2-hydroxy-2-phenylethyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

(S)-styrene oxide (20780-54-5) + (S)-3-benzoyloxypyrrolidine (259184-49-1) → Benzoic acid (S)-1-((R)-2-hydroxy-1-phenyl-ethyl)-pyrrolidin-3-yl ester + (2'S,3S)-3-benzoyloxy-N-(2-hydroxy-2-phenylethyl)pyrrolidine (259184-51-5)

Guidance literature:

In 1-methyl-pyrrolidin-2-one; at 100 ℃; for 12h;

DOI:10.1016/S0957-4166(03)00581-0

Reference yield: 80.0%

4-(N-methylamino)-N-propylbenzamide (204973-14-8) + (2'S,3S)-3-benzoyloxy-N-(2-hydroxy-2-phenylethyl)pyrrolidine (259184-51-5) → (2'S,3S)-3-benzoyloxy-N-{2-[N-methyl-N-4-(N-propylaminocarbonyl)phenyl]amino-2-phenyl}ethylpyrrolidine (473916-34-6)

Guidance literature:

(2'S,3S)-3-benzoyloxy-N-(2-hydroxy-2-phenylethyl)pyrrolidine; With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 - 20 ℃;

4-(N-methylamino)-N-propylbenzamide; In dichloromethane; for 12h; Heating;

DOI:10.1016/S0957-4166(03)00581-0

Reference yield: 64.0%

(2'S,3S)-3-benzoyloxy-N-(2-hydroxy-2-phenylethyl)pyrrolidine (259184-51-5) → (2'S,3S)-3-benzoyloxy-N-(2-chloro-2-phenylethyl)pyrrolidine

Guidance literature:

With methanesulfonyl chloride; triethylamine; In dichloromethane; for 0.5h;

DOI:10.1016/S0957-4166(03)00581-0

upstream raw materials:

(S)-styrene oxide

(S)-3-benzoyloxypyrrolidine

Downstream raw materials:

(2'S,3S)-3-benzoyloxy-N-{2-[N-methyl-N-4-(N-propylaminocarbonyl)phenyl]amino-2-phenyl}ethylpyrrolidine

(2'S,3S)-3-hydroxy-N-{2-[N-methyl-N-4-(N-propylaminocarbonyl)phenyl]amino-2-phenyl}ethylpyrrolidine