Technology Process of 1-(5-tert-butylisoxazol-3-yl)-3-[3-(7-ethoxy-6-methoxyquinazolin-4-ylthio)phenyl]urea
There total 6 articles about 1-(5-tert-butylisoxazol-3-yl)-3-[3-(7-ethoxy-6-methoxyquinazolin-4-ylthio)phenyl]urea which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
caesium carbonate;
In
isopropyl alcohol;
at 70 ℃;
for 7h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 70 °C
2.1: nitric acid; acetic anhydride / acetic acid / 20 - 50 °C
3.1: hydrogen / palladium 10% on activated carbon / methanol / 6 h / 20 °C / 760.05 Torr
4.1: formamide / 8 h / 130 °C
5.1: trichlorophosphate / toluene / 5 h / 125 °C
5.2: Saturated solution
6.1: caesium carbonate / isopropyl alcohol / 7 h / 70 °C
With
hydrogen; nitric acid; acetic anhydride; potassium carbonate; caesium carbonate; trichlorophosphate;
palladium 10% on activated carbon;
In
methanol; formamide; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: nitric acid; acetic anhydride / acetic acid / 20 - 50 °C
2.1: hydrogen / palladium 10% on activated carbon / methanol / 6 h / 20 °C / 760.05 Torr
3.1: formamide / 8 h / 130 °C
4.1: trichlorophosphate / toluene / 5 h / 125 °C
4.2: Saturated solution
5.1: caesium carbonate / isopropyl alcohol / 7 h / 70 °C
With
hydrogen; nitric acid; acetic anhydride; caesium carbonate; trichlorophosphate;
palladium 10% on activated carbon;
In
methanol; formamide; acetic acid; isopropyl alcohol; toluene;
