1-(5-tert-butylisoxazol-3-yl)-3-[3-(7-ethoxy-6-methoxyquinazolin-4-ylthio)phenyl]urea

Base Information

Chemical Name:1-(5-tert-butylisoxazol-3-yl)-3-[3-(7-ethoxy-6-methoxyquinazolin-4-ylthio)phenyl]urea
CAS No.:1188907-44-9
Molecular Formula:C₂₅H₂₇N₅O₄S
Molecular Weight:493.586
Hs Code.:

Synonyms:1-(5-tert-butylisoxazol-3-yl)-3-[3-(7-ethoxy-6-methoxyquinazolin-4-ylthio)phenyl]urea

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Chemical Property of 1-(5-tert-butylisoxazol-3-yl)-3-[3-(7-ethoxy-6-methoxyquinazolin-4-ylthio)phenyl]urea

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Technology Process of 1-(5-tert-butylisoxazol-3-yl)-3-[3-(7-ethoxy-6-methoxyquinazolin-4-ylthio)phenyl]urea

There total 6 articles about 1-(5-tert-butylisoxazol-3-yl)-3-[3-(7-ethoxy-6-methoxyquinazolin-4-ylthio)phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1188907-35-8
1-(5-tert-butylisoxazol-3-yl)-3-(3-mercaptophenyl)urea

: 643084-72-4
4-chloro-7-ethoxy-6-methoxy-quinazoline

: 1188907-44-9
1-(5-tert-butylisoxazol-3-yl)-3-[3-(7-ethoxy-6-methoxyquinazolin-4-ylthio)phenyl]urea

Guidance literature:: With caesium carbonate; In isopropyl alcohol; at 70 ℃; for 7h;

Reference yield:

: 3943-74-6
4-hydroxy-3-methoxybenzoic acid methyl ester

: 1188907-44-9
1-(5-tert-butylisoxazol-3-yl)-3-[3-(7-ethoxy-6-methoxyquinazolin-4-ylthio)phenyl]urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 70 °C

2.1: nitric acid; acetic anhydride / acetic acid / 20 - 50 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 6 h / 20 °C / 760.05 Torr

4.1: formamide / 8 h / 130 °C

5.1: trichlorophosphate / toluene / 5 h / 125 °C

5.2: Saturated solution

6.1: caesium carbonate / isopropyl alcohol / 7 h / 70 °C

With hydrogen; nitric acid; acetic anhydride; potassium carbonate; caesium carbonate; trichlorophosphate; palladium 10% on activated carbon; In methanol; formamide; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

Reference yield:

: 3535-24-8
4-ethoxy-3-methoxybenzoic acid methyl ester

: 1188907-44-9
1-(5-tert-butylisoxazol-3-yl)-3-[3-(7-ethoxy-6-methoxyquinazolin-4-ylthio)phenyl]urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: nitric acid; acetic anhydride / acetic acid / 20 - 50 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 6 h / 20 °C / 760.05 Torr

3.1: formamide / 8 h / 130 °C

4.1: trichlorophosphate / toluene / 5 h / 125 °C

4.2: Saturated solution

5.1: caesium carbonate / isopropyl alcohol / 7 h / 70 °C

With hydrogen; nitric acid; acetic anhydride; caesium carbonate; trichlorophosphate; palladium 10% on activated carbon; In methanol; formamide; acetic acid; isopropyl alcohol; toluene;