4-[5-(2,4-diamino-6-oxo-1,6-dihydro-pyrimidin-5-ylmethyl)-pyridin-3-yl]-benzoic acid

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Chemical Name:4-[5-(2,4-diamino-6-oxo-1,6-dihydro-pyrimidin-5-ylmethyl)-pyridin-3-yl]-benzoic acid
CAS No.:289677-39-0
Molecular Formula:C₁₇H₁₅N₅O₃
Molecular Weight:337.338
Hs Code.:

Synonyms:4-[5-(2,4-diamino-6-oxo-1,6-dihydro-pyrimidin-5-ylmethyl)-pyridin-3-yl]-benzoic acid

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Chemical Property of 4-[5-(2,4-diamino-6-oxo-1,6-dihydro-pyrimidin-5-ylmethyl)-pyridin-3-yl]-benzoic acid

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Technology Process of 4-[5-(2,4-diamino-6-oxo-1,6-dihydro-pyrimidin-5-ylmethyl)-pyridin-3-yl]-benzoic acid

There total 3 articles about 4-[5-(2,4-diamino-6-oxo-1,6-dihydro-pyrimidin-5-ylmethyl)-pyridin-3-yl]-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 289677-38-9
4-[5-(2,4-diamino-6-oxo-1,6-dihydro-pyrimidin-5-ylmethyl)-pyridin-3-yl]-benzoic acid methyl ester

: 289677-39-0
4-[5-(2,4-diamino-6-oxo-1,6-dihydro-pyrimidin-5-ylmethyl)-pyridin-3-yl]-benzoic acid

Guidance literature:: With lithium hydroxide; water; In methanol; at 25 ℃; for 12h;
DOI:10.1016/S0968-0896(00)00051-1

Reference yield:

: 619-42-1
4-methoxycarbonylphenyl bromide

: 289677-39-0
4-[5-(2,4-diamino-6-oxo-1,6-dihydro-pyrimidin-5-ylmethyl)-pyridin-3-yl]-benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: diboron pinacol ester; KOAc; PdCl₂(dppf) / dimethylformamide / 2 h / 80 °C

1.2: 54 percent / PdCl₂(dppf); aq. Na₂CO₃ / dimethylformamide / 12 h / 80 °C

2.1: 90 percent / Bu₄NF / tetrahydrofuran / 3 h / 25 °C

3.1: 92 percent / SOCl₂ / CH₂Cl₂ / 3 h / 50 °C

4.1: 79 percent / K₂CO₃ / dimethylformamide / 3 h / 70 °C

5.1: 61 percent / NaOEt / ethanol / 12 h / 45 °C

6.1: 88 percent / LiOH; H₂O / methanol / 12 h / 25 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium hydroxide; thionyl chloride; tetrabutyl ammonium fluoride; water; sodium ethanolate; potassium acetate; potassium carbonate; bis(pinacol)diborane; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 1.1: Substitution / 1.2: Condensation / 2.1: silyl ether cleavage / 3.1: Chlorination / 4.1: Alkylation / 5.1: cyclocondensation / 6.1: Hydrolysis;
DOI:10.1016/S0968-0896(00)00051-1

Reference yield:

: 289677-35-6
methyl 4-[5-hydroxymethyl-3-pyridinyl]benzoate

: 289677-39-0
4-[5-(2,4-diamino-6-oxo-1,6-dihydro-pyrimidin-5-ylmethyl)-pyridin-3-yl]-benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / SOCl₂ / CH₂Cl₂ / 3 h / 50 °C

2: 79 percent / K₂CO₃ / dimethylformamide / 3 h / 70 °C

3: 61 percent / NaOEt / ethanol / 12 h / 45 °C

4: 88 percent / LiOH; H₂O / methanol / 12 h / 25 °C

With lithium hydroxide; thionyl chloride; water; sodium ethanolate; potassium carbonate; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 1: Chlorination / 2: Alkylation / 3: cyclocondensation / 4: Hydrolysis;
DOI:10.1016/S0968-0896(00)00051-1