(3R)-3-tert-butoxycarbonylamino-1-nitro-2-oxo-4-phenylbutane

Base Information

• Chemical Name: (3R)-3-tert-butoxycarbonylamino-1-nitro-2-oxo-4-phenylbutane
• CAS No.: 1309075-86-2
• Molecular Formula: C₁₅H₂₀N₂O₅
• Molecular Weight: 308.334
• Mol file: 1309075-86-2.mol

Synonyms:(3R)-3-tert-butoxycarbonylamino-1-nitro-2-oxo-4-phenylbutane

Chemical Property of (3R)-3-tert-butoxycarbonylamino-1-nitro-2-oxo-4-phenylbutane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R)-3-tert-butoxycarbonylamino-1-nitro-2-oxo-4-phenylbutane

There total 4 articles about (3R)-3-tert-butoxycarbonylamino-1-nitro-2-oxo-4-phenylbutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

nitromethane (75-52-5) + (2S)-2-[N-(tert-butoxycarbonyl)amino]-1-imidazol-1-yl-3-phenylpropan-1-one (34101-07-0) → (3R)-3-tert-butoxycarbonylamino-1-nitro-2-oxo-4-phenylbutane (1309075-86-2) + (S)-3-tert-butoxycarbonylamino-1-nitro-4-phenyl-2-butanone (174302-72-8)

Guidance literature:

nitromethane; With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 1h;

(2S)-2-[N-(tert-butoxycarbonyl)amino]-1-imidazol-1-yl-3-phenylpropan-1-one; In tetrahydrofuran; at 20 ℃; for 15h;

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → (3R)-3-tert-butoxycarbonylamino-1-nitro-2-oxo-4-phenylbutane (1309075-86-2) + (S)-3-tert-butoxycarbonylamino-1-nitro-4-phenyl-2-butanone (174302-72-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dichloromethane / 1 h / -7 - -3 °C / Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 1 h / 0 °C

2.2: 15 h / 20 °C

With potassium tert-butylate; In tetrahydrofuran; dichloromethane;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → (3R)-3-tert-butoxycarbonylamino-1-nitro-2-oxo-4-phenylbutane (1309075-86-2) + (S)-3-tert-butoxycarbonylamino-1-nitro-4-phenyl-2-butanone (174302-72-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide; tetrabutylammomium bromide / water / 0.08 h / 25 - 30 °C

1.2: 16 h / 0 - 30 °C

2.1: dichloromethane / 1 h / -7 - -3 °C / Inert atmosphere

3.1: potassium tert-butylate / tetrahydrofuran / 1 h / 0 °C

3.2: 15 h / 20 °C

With potassium tert-butylate; tetrabutylammomium bromide; sodium hydroxide; In tetrahydrofuran; dichloromethane; water;

upstream raw materials:

nitromethane

(2S)-2-[N-(tert-butoxycarbonyl)amino]-1-imidazol-1-yl-3-phenylpropan-1-one

di-tert-butyl dicarbonate

L-phenylalanine