2-(4-hydroxyphenyl)-N-[5-(4-hydroxyphenyl)-3-(thiophen-2-yl)pyrazin-2-yl]acetamide

Base Information

Chemical Name:2-(4-hydroxyphenyl)-N-[5-(4-hydroxyphenyl)-3-(thiophen-2-yl)pyrazin-2-yl]acetamide
CAS No.:1338220-33-9
Molecular Formula:C₂₂H₁₇N₃O₃S
Molecular Weight:403.461
Hs Code.:

Synonyms:2-(4-hydroxyphenyl)-N-[5-(4-hydroxyphenyl)-3-(thiophen-2-yl)pyrazin-2-yl]acetamide

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Chemical Property of 2-(4-hydroxyphenyl)-N-[5-(4-hydroxyphenyl)-3-(thiophen-2-yl)pyrazin-2-yl]acetamide

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Technology Process of 2-(4-hydroxyphenyl)-N-[5-(4-hydroxyphenyl)-3-(thiophen-2-yl)pyrazin-2-yl]acetamide

There total 10 articles about 2-(4-hydroxyphenyl)-N-[5-(4-hydroxyphenyl)-3-(thiophen-2-yl)pyrazin-2-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.6%

: 2-[4-(tert-butyldimethylsilyloxy)phenyl]-N-[5-{4-(tert-butyldimethylsilyloxy)phenyl}-3-(thiophen-2-yl)pyrazin-2-yl]acetamide

: 1338220-33-9
2-(4-hydroxyphenyl)-N-[5-(4-hydroxyphenyl)-3-(thiophen-2-yl)pyrazin-2-yl]acetamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

Reference yield:

: 549503-20-0
5-(p-tert-butyldimethylsilyloxyphenyl)-2-amino-1,4-pyrazine

: 1338220-33-9
2-(4-hydroxyphenyl)-N-[5-(4-hydroxyphenyl)-3-(thiophen-2-yl)pyrazin-2-yl]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide / dimethyl sulfoxide; water / 17 h / 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 14 h / Inert atmosphere; Reflux

2.2: 0.5 h / 20 °C / Inert atmosphere

3.1: dmap; pyridine / 15 h / 50 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C

With pyridine; dmap; bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,4-dioxane; water; dimethyl sulfoxide;

Reference yield:

: 159191-56-7
(4-((tert-butyldimethylsilyl)oxy)phenyl)boronic acid

: 1338220-33-9
2-(4-hydroxyphenyl)-N-[5-(4-hydroxyphenyl)-3-(thiophen-2-yl)pyrazin-2-yl]acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / toluene; ethanol; water / 17 h / Inert atmosphere; Reflux

2.1: N-Bromosuccinimide / dimethyl sulfoxide; water / 17 h / 20 °C

3.1: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 14 h / Inert atmosphere; Reflux

3.2: 0.5 h / 20 °C / Inert atmosphere

4.1: dmap; pyridine / 15 h / 50 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C

With pyridine; dmap; bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; tetrabutyl ammonium fluoride; sodium carbonate; In tetrahydrofuran; 1,4-dioxane; ethanol; water; dimethyl sulfoxide; toluene;