Acetic acid, [[[(3beta,7alpha,19E)-7-(acetyloxy)-3-hydroxy-17-oxoandrost-5-en-19-

Base Information

Chemical Name:Acetic acid, [[[(3beta,7alpha,19E)-7-(acetyloxy)-3-hydroxy-17-oxoandrost-5-en-19-
CAS No.:213695-80-8
Molecular Formula:C₂₄H₃₃NO₇
Molecular Weight:447.529
Hs Code.:

Synonyms:Acetic acid, [[[(3beta,7alpha,19E)-7-(acetyloxy)-3-hydroxy-17-oxoandrost-5-en-19-

Suppliers and Price of Acetic acid, [[[(3beta,7alpha,19E)-7-(acetyloxy)-3-hydroxy-17-oxoandrost-5-en-19-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Acetic acid, [[[(3beta,7alpha,19E)-7-(acetyloxy)-3-hydroxy-17-oxoandrost-5-en-19-

Chemical Property:

PSA：111.49000
LogP:2.57630

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Acetic acid, [[[(3beta,7alpha,19E)-7-(acetyloxy)-3-hydroxy-17-oxoandrost-5-en-19-

There total 10 articles about Acetic acid, [[[(3beta,7alpha,19E)-7-(acetyloxy)-3-hydroxy-17-oxoandrost-5-en-19- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 213695-79-5
(19E)-17,19-dioxoandrost-5-ene-3β,7α-diyl 3,7-diacetate 19-(O-methoxycarbonylmethyl)oxime

: 213695-81-9,188176-13-8
(19E)-3β,7α-dihydroxy-17-oxoandrost-5-en-19-al 19-(O-methoxycarbonylmethyl)oxime

: 213695-80-8
(19E)-17,19-dioxo-3β-hydroxyandrost-5-en-7α-yl 7-acetate 19-(O-methoxycarbonylmethyl)oxime

Guidance literature:: With methanol; sodium hydroxide; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, MeOH, RT, 5 d, 2.) ether, 0 deg C, 5 min;
DOI:10.1016/S0039-128X(98)00047-6

Reference yield:

: 17,17-ethylenedioxy-19-hydrxyandrost-5-en-3β-yl acetate

: 213695-80-8
(19E)-17,19-dioxo-3β-hydroxyandrost-5-en-7α-yl 7-acetate 19-(O-methoxycarbonylmethyl)oxime

Guidance literature:: Multi-step reaction with 10 steps

1: 92 percent / imidazole / dimethylformamide / Ambient temperature

2: 64 percent / chromium(VI) oxide, 3,5-dimethylpyrazole / CH₂Cl₂ / 4.5 h / -20 °C

3: 1.) lithium tri-sec-butylborohydride, 2.) aq. NaOH, 30percent H₂O₂ / 1.) THF, -78 deg C, 5 h, 2.) THF, RT, 30 min

4: pyridine / 10 h / Ambient temperature

5: tetrabutylammonium fluoride / tetrahydrofuran / 24 h / Ambient temperature

6: chromium(VI) oxide, pyridine, MgSO₄ / CH₂Cl₂ / 3 h / 0 °C

7: pyridine / 60 h / Ambient temperature

8: MeOH / diethyl ether / 0.08 h / 0 °C

9: 76 percent / aq. p-TsOH*H₂O / acetone / 120 h / Ambient temperature

10: 1.) aq. NaOH, 2.) MeOH / 1.) THF, MeOH, RT, 5 d, 2.) ether, 0 deg C, 5 min

With pyridine; 1H-imidazole; 3,5-dimethyl-1H-pyrazole; chromium(VI) oxide; methanol; sodium hydroxide; tetrabutyl ammonium fluoride; dihydrogen peroxide; L-Selectride; magnesium sulfate; toluene-4-sulfonic acid; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0039-128X(98)00047-6

Reference yield:

: 213695-76-2
17,17-ethylenedioxy-19-hydroxyandrost-5-ene-3β,7α-diyl diacetate

: 213695-80-8
(19E)-17,19-dioxo-3β-hydroxyandrost-5-en-7α-yl 7-acetate 19-(O-methoxycarbonylmethyl)oxime

Guidance literature:: Multi-step reaction with 5 steps

1: chromium(VI) oxide, pyridine, MgSO₄ / CH₂Cl₂ / 3 h / 0 °C

2: pyridine / 60 h / Ambient temperature

3: MeOH / diethyl ether / 0.08 h / 0 °C

4: 76 percent / aq. p-TsOH*H₂O / acetone / 120 h / Ambient temperature

5: 1.) aq. NaOH, 2.) MeOH / 1.) THF, MeOH, RT, 5 d, 2.) ether, 0 deg C, 5 min

With pyridine; chromium(VI) oxide; methanol; sodium hydroxide; magnesium sulfate; toluene-4-sulfonic acid; In diethyl ether; dichloromethane; acetone;
DOI:10.1016/S0039-128X(98)00047-6