t-Butyl (S,S)-N-<3-(2-t-butoxycarbonylamino-3-hydroxypropyl)-7-(2-methyl-3-buten-2-yl)-4-indolyl>-N-methylvalinate

Base Information

Chemical Name:t-Butyl (S,S)-N-<3-(2-t-butoxycarbonylamino-3-hydroxypropyl)-7-(2-methyl-3-buten-2-yl)-4-indolyl>-N-methylvalinate
CAS No.:138395-27-4
Molecular Formula:C₃₁H₄₉N₃O₅
Molecular Weight:543.747
Hs Code.:

Synonyms:t-Butyl (S,S)-N-<3-(2-t-butoxycarbonylamino-3-hydroxypropyl)-7-(2-methyl-3-buten-2-yl)-4-indolyl>-N-methylvalinate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of t-Butyl (S,S)-N-<3-(2-t-butoxycarbonylamino-3-hydroxypropyl)-7-(2-methyl-3-buten-2-yl)-4-indolyl>-N-methylvalinate

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Technology Process of t-Butyl (S,S)-N-<3-(2-t-butoxycarbonylamino-3-hydroxypropyl)-7-(2-methyl-3-buten-2-yl)-4-indolyl>-N-methylvalinate

There total 2 articles about t-Butyl (S,S)-N-<3-(2-t-butoxycarbonylamino-3-hydroxypropyl)-7-(2-methyl-3-buten-2-yl)-4-indolyl>-N-methylvalinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 138372-12-0
t-Butyl (S,S)-N-<4-<4-(3-t-butoxycarbonyl-2,2-dimethyloxazolidin-4-yl)methylpyrrol-2-yl>-5,5-dimethyl-1-thioxo-3,6-heptadienyl>-N-methylvalinate

: 89066-57-9
Bis(2-methoxycarbonylbenzyl) sulfide

: 138395-27-4
t-Butyl (S,S)-N-<3-(2-t-butoxycarbonylamino-3-hydroxypropyl)-7-(2-methyl-3-buten-2-yl)-4-indolyl>-N-methylvalinate

: 138372-14-2
(S)-4-[7-(1,1-Dimethyl-allyl)-4-(2-methoxycarbonyl-benzylsulfanyl)-1H-indol-3-ylmethyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 138395-26-3
t-Butyl (S,S)-N-<3-<(3-t-butoxycarbonyl-2,2-dimethyloxazolidin-4-yl)-methyl>-7-(2-methyl-3-buten-2-yl)-4-indolyl>-N-methylvalinate

Guidance literature:: With methyl 2-bromomethylbenzoate; 2-methyl-but-2-ene; In N,N-dimethyl-formamide; at 45 ℃; for 6.66667h; Further byproducts given;
DOI:10.1016/S0040-4020(01)88285-5

Reference yield: 45.0%

: 2417-73-4
methyl 2-bromomethylbenzoate

: 138372-12-0
t-Butyl (S,S)-N-<4-<4-(3-t-butoxycarbonyl-2,2-dimethyloxazolidin-4-yl)methylpyrrol-2-yl>-5,5-dimethyl-1-thioxo-3,6-heptadienyl>-N-methylvalinate

: 89066-57-9
Bis(2-methoxycarbonylbenzyl) sulfide

: 138395-27-4
t-Butyl (S,S)-N-<3-(2-t-butoxycarbonylamino-3-hydroxypropyl)-7-(2-methyl-3-buten-2-yl)-4-indolyl>-N-methylvalinate

: 138372-14-2
(S)-4-[7-(1,1-Dimethyl-allyl)-4-(2-methoxycarbonyl-benzylsulfanyl)-1H-indol-3-ylmethyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 138395-26-3
t-Butyl (S,S)-N-<3-<(3-t-butoxycarbonyl-2,2-dimethyloxazolidin-4-yl)-methyl>-7-(2-methyl-3-buten-2-yl)-4-indolyl>-N-methylvalinate

Guidance literature:: With 2-methyl-but-2-ene; In N,N-dimethyl-formamide; at 45 ℃; for 6.66667h; Further byproducts given;
DOI:10.1016/S0040-4020(01)88285-5

Reference yield:

: 138395-27-4
t-Butyl (S,S)-N-<3-(2-t-butoxycarbonylamino-3-hydroxypropyl)-7-(2-methyl-3-buten-2-yl)-4-indolyl>-N-methylvalinate

: 119375-01-8,138512-90-0
(-)-pendolmycin

Guidance literature:: With triethylamine; diethyl dicarbonate; trifluoroacetic acid; Yield given. Multistep reaction; 1.) 24 deg C, 17.5 h, 2.) DMF, 24 deg C, 21 h;
DOI:10.1016/S0040-4020(01)88285-5