methyl-3-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamido)propanoate

Base Information

Chemical Name:methyl-3-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamido)propanoate
CAS No.:1447710-83-9
Molecular Formula:C₂₈H₄₀N₂O₅
Molecular Weight:484.636
Hs Code.:

Synonyms:methyl-3-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamido)propanoate

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Chemical Property of methyl-3-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamido)propanoate

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Technology Process of methyl-3-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamido)propanoate

There total 10 articles about methyl-3-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1447711-40-1
5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxylic acid

: 3196-73-4
methyl 3-aminopropanoate hydrochloride

: 1447710-83-9
methyl-3-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamido)propanoate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 25 ℃;
DOI:10.1016/j.ejmech.2013.09.015

Reference yield:

: 499-76-3
4-hydroxy-3-methylbenzoic acid

: 1447710-83-9
methyl-3-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamido)propanoate

Guidance literature:: Multi-step reaction with 9 steps

1.1: sulfuric acid / 6 h / Reflux

2.1: potassium carbonate; potassium iodide / 6 h / Reflux

3.1: diethyl ether / 2 h / 0 - 30 °C

4.1: boron trifluoride diethyl etherate / dichloromethane / 1 h / 0 - 25 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

5.2: 2 h / 25 °C

6.1: palladium on activated charcoal; ammonium formate / methanol / 25 °C

7.1: potassium carbonate; potassium iodide / acetone / 12 h / Reflux

8.1: potassium hydroxide; water / ethanol / 5 h / 80 °C

9.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 25 °C

With sulfuric acid; palladium on activated charcoal; boron trifluoride diethyl etherate; water; ammonium formate; sodium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium iodide; potassium hydroxide; In methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.ejmech.2013.09.015

Reference yield:

: 2199-43-1
ethyl 1H-pyrrole-2-carboxylate

: 1447710-83-9
methyl-3-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamido)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: boron trifluoride diethyl etherate / dichloromethane / 1 h / 0 - 25 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.2: 2 h / 25 °C

3.1: palladium on activated charcoal; ammonium formate / methanol / 25 °C

4.1: potassium carbonate; potassium iodide / acetone / 12 h / Reflux

5.1: potassium hydroxide; water / ethanol / 5 h / 80 °C

6.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 25 °C

With palladium on activated charcoal; boron trifluoride diethyl etherate; water; ammonium formate; sodium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium iodide; potassium hydroxide; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.ejmech.2013.09.015