1-<<1,3(R)-bis(benzyloxy)-4-fluoro-2(R)-butoxy>methyl>-1,2,4-triazole-3-carboxamide

Base Information

Chemical Name:1-<<1,3(R)-bis(benzyloxy)-4-fluoro-2(R)-butoxy>methyl>-1,2,4-triazole-3-carboxamide
CAS No.:123903-66-2
Molecular Formula:C₂₂H₂₅FN₄O₄
Molecular Weight:428.463
Hs Code.:

Synonyms:1-<<1,3(R)-bis(benzyloxy)-4-fluoro-2(R)-butoxy>methyl>-1,2,4-triazole-3-carboxamide

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Chemical Property of 1-<<1,3(R)-bis(benzyloxy)-4-fluoro-2(R)-butoxy>methyl>-1,2,4-triazole-3-carboxamide

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Technology Process of 1-<<1,3(R)-bis(benzyloxy)-4-fluoro-2(R)-butoxy>methyl>-1,2,4-triazole-3-carboxamide

There total 6 articles about 1-<<1,3(R)-bis(benzyloxy)-4-fluoro-2(R)-butoxy>methyl>-1,2,4-triazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 123903-65-1
methyl 1-<<1,3(R)-bis(benzyloxy)-4-fluoro-2(R)-butoxy>methyl>-1,2,4-triazole-3-carboxylate

: 123903-66-2
1-<<1,3(R)-bis(benzyloxy)-4-fluoro-2(R)-butoxy>methyl>-1,2,4-triazole-3-carboxamide

Guidance literature:: With ammonia; In methanol; for 68h; Ambient temperature;
DOI:10.1021/jm00164a035

Reference yield:

: 123903-55-9
(R,R)-3-(benzyloxy)-1,2-epoxy-4-fluorobutane

: 123903-66-2
1-<<1,3(R)-bis(benzyloxy)-4-fluoro-2(R)-butoxy>methyl>-1,2,4-triazole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 82.4 percent / aq. NaOH / 2-methyl-propan-2-ol / 3 h / 90 °C

2: 88.2 percent / HCl / CH₂Cl₂ / ice-bath temp.

3: 1.) ammonium sulfate, hexamethyldisilazane 2.) tetrabutylammonium iodide / 1.) reflux, overnight, 2.) a) acetonitrile, reflux, 4.5 h, b) room temp., 3 d

4: 100 percent / ammonia / methanol / 68 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; ammonium sulfate; ammonia; tetra-(n-butyl)ammonium iodide; 1,1,1,3,3,3-hexamethyl-disilazane; In methanol; dichloromethane; tert-butyl alcohol;
DOI:10.1021/jm00164a035

Reference yield:

: 123903-54-8
(R,R)-3-O-benzyl-4-fluoro-1,2,3-butanetriol

: 123903-66-2
1-<<1,3(R)-bis(benzyloxy)-4-fluoro-2(R)-butoxy>methyl>-1,2,4-triazole-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 77.7 percent / diisopropyl diazodicarboxylate, triphenylphosphine / benzene

2: 82.4 percent / aq. NaOH / 2-methyl-propan-2-ol / 3 h / 90 °C

3: 88.2 percent / HCl / CH₂Cl₂ / ice-bath temp.

4: 1.) ammonium sulfate, hexamethyldisilazane 2.) tetrabutylammonium iodide / 1.) reflux, overnight, 2.) a) acetonitrile, reflux, 4.5 h, b) room temp., 3 d

5: 100 percent / ammonia / methanol / 68 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; ammonium sulfate; di-isopropyl azodicarboxylate; ammonia; tetra-(n-butyl)ammonium iodide; triphenylphosphine; 1,1,1,3,3,3-hexamethyl-disilazane; In methanol; dichloromethane; tert-butyl alcohol; benzene;
DOI:10.1021/jm00164a035