3-[3-fluoro-4-[methylsulfonyl]phenyl]-5-{1-[4-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}-1,2,4-oxadiazole

Base Information

Chemical Name:3-[3-fluoro-4-[methylsulfonyl]phenyl]-5-{1-[4-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}-1,2,4-oxadiazole
CAS No.:1263320-67-7
Molecular Formula:C₂₃H₂₃FN₄O₅S
Molecular Weight:486.524
Hs Code.:

Synonyms:3-[3-fluoro-4-[methylsulfonyl]phenyl]-5-{1-[4-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}-1,2,4-oxadiazole

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Chemical Property of 3-[3-fluoro-4-[methylsulfonyl]phenyl]-5-{1-[4-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}-1,2,4-oxadiazole

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Technology Process of 3-[3-fluoro-4-[methylsulfonyl]phenyl]-5-{1-[4-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}-1,2,4-oxadiazole

There total 7 articles about 3-[3-fluoro-4-[methylsulfonyl]phenyl]-5-{1-[4-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1263320-51-9
2-[4-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenoxy]butyric acid

: 1263320-48-4
3-fluoro-N'-hydroxy-4-(methylsulfonyl)benzenecarboximidamide

: 1263320-67-7
3-[3-fluoro-4-[methylsulfonyl]phenyl]-5-{1-[4-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}-1,2,4-oxadiazole

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 100 ℃; for 5h;

Reference yield:

: 185946-04-7
3-fluoro-4-methylsulfanyl-benzonitrile

: 1263320-67-7
3-[3-fluoro-4-[methylsulfonyl]phenyl]-5-{1-[4-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 19.5 h / 20 °C / Cooling with ice

2: hydroxylamine / ethanol; water / 1 h / 20 °C / Cooling with ice

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 5 h / 100 °C

With hydroxylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 79228-67-4
Ethyl 2-(4-cyanophenoxy)butanoate

: 1263320-67-7
3-[3-fluoro-4-[methylsulfonyl]phenyl]-5-{1-[4-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 4 steps

1: hydroxylamine / ethanol; water / 2.5 h / 80 °C

2: pyridine / 2 h / 100 °C

3: sodium hydroxide; water / tetrahydrofuran; methanol / 0.5 h / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 5 h / 100 °C

With pyridine; water; hydroxylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;