4-((3-methyl-3H-imidazol-4-ylmethyl)-{2-[(tetrahydropyran-4-ylmethyl)amino]ethyl}amino)benzonitrile

Base Information

Chemical Name:4-((3-methyl-3H-imidazol-4-ylmethyl)-{2-[(tetrahydropyran-4-ylmethyl)amino]ethyl}amino)benzonitrile
CAS No.:910910-88-2
Molecular Formula:C₂₀H₂₇N₅O
Molecular Weight:353.467
Hs Code.:

Synonyms:4-((3-methyl-3H-imidazol-4-ylmethyl)-{2-[(tetrahydropyran-4-ylmethyl)amino]ethyl}amino)benzonitrile

Suppliers and Price of 4-((3-methyl-3H-imidazol-4-ylmethyl)-{2-[(tetrahydropyran-4-ylmethyl)amino]ethyl}amino)benzonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-((3-methyl-3H-imidazol-4-ylmethyl)-{2-[(tetrahydropyran-4-ylmethyl)amino]ethyl}amino)benzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-((3-methyl-3H-imidazol-4-ylmethyl)-{2-[(tetrahydropyran-4-ylmethyl)amino]ethyl}amino)benzonitrile

There total 6 articles about 4-((3-methyl-3H-imidazol-4-ylmethyl)-{2-[(tetrahydropyran-4-ylmethyl)amino]ethyl}amino)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 4-[(2-aminoethyl)-(3-methyl-3H-imidazol-4-ylmethyl)amino]benzonitrile ditrifluoroacetic acid

: 50675-18-8
3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde

: 910910-88-2
4-((3-methyl-3H-imidazol-4-ylmethyl)-{2-[(tetrahydropyran-4-ylmethyl)amino]ethyl}amino)benzonitrile

Guidance literature:: 4-[(2-aminoethyl)-(3-methyl-3H-imidazol-4-ylmethyl)amino]benzonitrile ditrifluoroacetic acid; 3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde; With acetic acid; In methanol; at 20 ℃; for 1h; Molecular sieve;

With sodium cyanoborohydride; In methanol; for 1h;

Reference yield:

: 4-[(3-Methyl-3H-imidazol-4-ylmethyl)-(2-{[1-(tetrahydro-pyran-4-yl)-meth-(Z)-ylidene]-amino}-ethyl)-amino]-benzonitrile

: 910910-88-2
4-((3-methyl-3H-imidazol-4-ylmethyl)-{2-[(tetrahydropyran-4-ylmethyl)amino]ethyl}amino)benzonitrile

Guidance literature:: With sodium cyanoborohydride; In methanol; at 20 ℃; for 1h;
DOI:10.1021/jm060081v

Reference yield:

: 865788-36-9
{2-[(4-cyanophenyl)amino]ethyl}carbamic acid tert-butyl ester

: 910910-88-2
4-((3-methyl-3H-imidazol-4-ylmethyl)-{2-[(tetrahydropyran-4-ylmethyl)amino]ethyl}amino)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol / 0.33 h

1.2: 85 percent / sodium cyanoborohydride / methanol / 50 °C

2.1: acetic acid; molecular sieves / methanol / 1 h / 20 °C

3.1: NaCNBH₃ / methanol / 1 h / 20 °C

With molecular sieve; sodium cyanoborohydride; acetic acid; In methanol;
DOI:10.1021/jm060081v