Technology Process of Boc-D-Phe(4-Tfa-AMe)-Phe(4-Tfa-AMe)-4-cyanobenzylamide
There total 10 articles about Boc-D-Phe(4-Tfa-AMe)-Phe(4-Tfa-AMe)-4-cyanobenzylamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: hydrogen / palladium 10% on activated carbon / 40 °C
2: N-ethyl-N,N-diisopropylamine / methanol / 1 h
3: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0 - 20 °C
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine;
palladium 10% on activated carbon;
In
methanol; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium hydroxide / water; tert-butyl alcohol / 20 °C
2: hydrogen / palladium 10% on activated carbon / 40 °C
3: N-ethyl-N,N-diisopropylamine / methanol / 1 h
4: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0 - 20 °C
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
palladium 10% on activated carbon;
In
methanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;