1-<2-deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythro-pentofuranosyl>-4-<<(9H-fluoren-9-yl)methoxy>carbonylamino>benzimidazole

Base Information

• Chemical Name: 1-<2-deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythro-pentofuranosyl>-4-<<(9H-fluoren-9-yl)methoxy>carbonylamino>benzimidazole
• CAS No.: 169382-21-2
• Molecular Formula: C₄₈H₄₃N₃O₇
• Molecular Weight: 773.885
• Mol file: 169382-21-2.mol

Synonyms:1-<2-deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythro-pentofuranosyl>-4-<<(9H-fluoren-9-yl)methoxy>carbonylamino>benzimidazole

Chemical Property of 1-<2-deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythro-pentofuranosyl>-4-<<(9H-fluoren-9-yl)methoxy>carbonylamino>benzimidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<2-deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythro-pentofuranosyl>-4-<<(9H-fluoren-9-yl)methoxy>carbonylamino>benzimidazole

There total 7 articles about 1-<2-deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythro-pentofuranosyl>-4-<<(9H-fluoren-9-yl)methoxy>carbonylamino>benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + 1-(2-deoxy-β-D-erythro-pentofuranosyl)-4-<<(9H-fluoren-9-yl)methoxy>carbonylamino>benzimidazole (169382-19-8) → 1-<2-deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythro-pentofuranosyl>-4-<<(9H-fluoren-9-yl)methoxy>carbonylamino>benzimidazole (169382-21-2)

Guidance literature:

In pyridine; for 1.5h;

DOI:10.1002/hlca.19950780405

Reference yield:

C26H25N3O5 → 1-<2-deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythro-pentofuranosyl>-4-<<(9H-fluoren-9-yl)methoxy>carbonylamino>benzimidazole (169382-21-2)

Guidance literature:

Multi-step reaction with 4 steps

1: ammonia / methanol; water

2: hydrazine hydrate / methanol / 16 h / 20 °C

3: pyridine; chloro-trimethyl-silane

4: pyridine

With pyridine; chloro-trimethyl-silane; ammonia; hydrazine hydrate; In methanol; water;

DOI:10.1002/chem.201002944

Reference yield:

2,6-dinitroaniline (606-22-4) → 1-<2-deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythro-pentofuranosyl>-4-<<(9H-fluoren-9-yl)methoxy>carbonylamino>benzimidazole (169382-21-2)

Guidance literature:

Multi-step reaction with 7 steps

1: sodium sulfide; sodium hydrogencarbonate / water

3: sodium hydride

4: ammonia / methanol; water

5: hydrazine hydrate / methanol / 16 h / 20 °C

6: pyridine; chloro-trimethyl-silane

7: pyridine

With pyridine; sodium sulfide; chloro-trimethyl-silane; ammonia; sodium hydride; sodium hydrogencarbonate; hydrazine hydrate; In methanol; water;

DOI:10.1002/chem.201002944

upstream raw materials:

4,4'-dimethoxytrityl chloride

1-(2-deoxy-β-D-erythro-pentofuranosyl)-4-<<(9H-fluoren-9-yl)methoxy>carbonylamino>benzimidazole

2,6-dinitroaniline

1,3-Dideaza-2'-deoxyadenosine