allyl (4R,5S,6S)-3-[(4-{4-[{[(allyloxy)carbonyl]amino}(imino)methyl]phenyl}-1,3-thiazol-2-yl)thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

Base Information

Chemical Name:allyl (4R,5S,6S)-3-[(4-{4-[{[(allyloxy)carbonyl]amino}(imino)methyl]phenyl}-1,3-thiazol-2-yl)thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
CAS No.:437649-96-2
Molecular Formula:C₂₇H₂₈N₄O₆S₂
Molecular Weight:568.675
Hs Code.:

allyl (4R,5S,6S)-3-[(4-{4-[{[(allyloxy)carbonyl]amino}(imino)methyl]phenyl}-1,3-thiazol-2-yl)thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

Synonyms:allyl (4R,5S,6S)-3-[(4-{4-[{[(allyloxy)carbonyl]amino}(imino)methyl]phenyl}-1,3-thiazol-2-yl)thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

Suppliers and Price of allyl (4R,5S,6S)-3-[(4-{4-[{[(allyloxy)carbonyl]amino}(imino)methyl]phenyl}-1,3-thiazol-2-yl)thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of allyl (4R,5S,6S)-3-[(4-{4-[{[(allyloxy)carbonyl]amino}(imino)methyl]phenyl}-1,3-thiazol-2-yl)thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of allyl (4R,5S,6S)-3-[(4-{4-[{[(allyloxy)carbonyl]amino}(imino)methyl]phenyl}-1,3-thiazol-2-yl)thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

There total 6 articles about allyl (4R,5S,6S)-3-[(4-{4-[{[(allyloxy)carbonyl]amino}(imino)methyl]phenyl}-1,3-thiazol-2-yl)thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 437649-95-1
allyl (4R,5S,6S)-3-[(4-{4-[{[(allyloxy)carbonyl]amino}(imino)methyl]phenyl}-1,3-thiazol-2-yl)thio]-4-methyl-7-oxo-6-{(1R)-1-[(trimethylsilyl)oxy]ethyl}-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

: 437649-96-2
allyl (4R,5S,6S)-3-[(4-{4-[{[(allyloxy)carbonyl]amino}(imino)methyl]phenyl}-1,3-thiazol-2-yl)thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 0 - 20 ℃;
DOI:10.7164/antibiotics.55.722

Reference yield:

: 52560-96-0
4-(2-mercapto-1,3-thiazol-4-yl)benzonitrile

: 437649-96-2
allyl (4R,5S,6S)-3-[(4-{4-[{[(allyloxy)carbonyl]amino}(imino)methyl]phenyl}-1,3-thiazol-2-yl)thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 65 percent / hydroxylamine hydrochloride; triethylamine / ethanol / 3 h / Heating

2: 39 percent / methanol / 6 h / 20 °C

3: 90 percent / tin(II) chloride; molecular sieves 4A / methanol / 1 h / Heating

4: 72 percent / sodium hydroxide / tetrahydrofuran; H₂O / 1.5 h / 0 °C

5: 63 percent / sodium hydride / acetonitrile / 72 h / 4 °C

6: 87 percent / hydrochloric acid / ethyl acetate / 0 - 20 °C

With hydrogenchloride; sodium hydroxide; 4 A molecular sieve; hydroxylamine hydrochloride; sodium hydride; triethylamine; tin(ll) chloride; In tetrahydrofuran; methanol; ethanol; water; ethyl acetate; acetonitrile;
DOI:10.7164/antibiotics.55.722

Reference yield:

: 437649-93-9
4-(2-mercapto-1,3-thiazol-4-yl)benzenecarboximidamide

: 437649-96-2
allyl (4R,5S,6S)-3-[(4-{4-[{[(allyloxy)carbonyl]amino}(imino)methyl]phenyl}-1,3-thiazol-2-yl)thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / sodium hydroxide / tetrahydrofuran; H₂O / 1.5 h / 0 °C

2: 63 percent / sodium hydride / acetonitrile / 72 h / 4 °C

3: 87 percent / hydrochloric acid / ethyl acetate / 0 - 20 °C

With hydrogenchloride; sodium hydroxide; sodium hydride; In tetrahydrofuran; water; ethyl acetate; acetonitrile;
DOI:10.7164/antibiotics.55.722