5-Chloro-3-nitroindole

Base Information

• Chemical Name: 5-Chloro-3-nitroindole
• CAS No.: 213542-01-9
• Molecular Formula: C8H5 Cl N2 O2
• Molecular Weight: 196.593
• Hs Code.: 2933990090
• Mol file: 213542-01-9.mol

Synonyms:5-Chloro-3-nitroindole

Chemical Property of 5-Chloro-3-nitroindole

Chemical Property:

• Melting Point: 218-220℃
• Boiling Point: 396℃
• Flash Point: 193℃
• PSA: 61.61000
• Density: 1.564
• LogP: 3.25270
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

5-chloro-3-nitro-1H-indole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Chloro-3-nitroindole

There total 5 articles about 5-Chloro-3-nitroindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C8H5ClN4O2 → 5-chloro-3-nitro-1H-indole (213542-01-9)

Guidance literature:

With bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]}; In toluene; at 75 ℃; for 16h; regioselective reaction; Inert atmosphere; Molecular sieve; Sealed tube;

DOI:10.1021/ja111060q

Reference yield: 60.0%

5-chloro-1H-indole (17422-32-1) → 5-chloro-3-nitro-1H-indole (213542-01-9)

Guidance literature:

With benzoyl chloride; silver nitrate; In acetonitrile; at 0 ℃; for 0.75h;

DOI:10.1016/j.bmc.2007.02.029

Reference yield:

C8H7ClN4O3 (1279718-30-7) → 5-chloro-3-nitro-1H-indole (213542-01-9)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; acetic anhydride / 20 °C / Inert atmosphere

2: bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]} / toluene / 16 h / 75 °C / Inert atmosphere; Molecular sieve; Sealed tube

With pyridine; bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]}; acetic anhydride; In toluene;

DOI:10.1021/ja111060q

upstream raw materials:

5-chloro-1H-indole

C₈H₇ClN₄O₃

5-chloro-2-nitrobenzaldehyde

2-azido 5-chlorobenzaldehyde

Downstream raw materials:

N-[2-(5-Chloro-1H-indol-3-ylamino)-phenyl]-acetamide

N-(5-Chloro-1H-indol-3-yl)-benzene-1,2-diamine

5-chloro-1H-indol-3-ylamine