C₄₁H₆₉NO₇SSi₃

Base Information

• Chemical Name: C₄₁H₆₉NO₇SSi₃
• CAS No.: 1266329-62-7
• Molecular Formula: C₄₁H₆₉NO₇SSi₃
• Molecular Weight: 804.324
• Mol file: 1266329-62-7.mol

Synonyms:C₄₁H₆₉NO₇SSi₃

Chemical Property of C₄₁H₆₉NO₇SSi₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₁H₆₉NO₇SSi₃

There total 7 articles about C₄₁H₆₉NO₇SSi₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

allenyl 2-deoxy-3,4,6-tri-O-t-butyldimethylsilyl-α-D-galactopyranoside (1055313-03-5) + N-(benzylidene)-p-methylbenzenesulfonamide (51608-60-7) → C41H69NO7SSi3 (1266329-62-7)

Guidance literature:

allenyl 2-deoxy-3,4,6-tri-O-t-butyldimethylsilyl-α-D-galactopyranoside; With n-butyllithium; lithium chloride; In tetrahydrofuran; cyclohexane; at -78 ℃; for 0.75h; Inert atmosphere;

N-(benzylidene)-p-methylbenzenesulfonamide; In tetrahydrofuran; cyclohexane; at -78 ℃; for 3h; Inert atmosphere;

With silver nitrate; In toluene; at 60 ℃; for 0.5h; optical yield given as %de; Inert atmosphere;

DOI:10.1021/ol103119u

Reference yield:

propargyl 3,4,6-tri-O-acetyl-2-deoxy-α-D-lyxo-hexopyranoside → C41H69NO7SSi3 (1266329-62-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: methanol; sodium methylate / 3 h / 20 °C / Inert atmosphere

2.1: 1H-imidazole; dmap / N,N-dimethyl-formamide / 48 h / 50 °C / Inert atmosphere

3.1: potassium tert-butylate / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

4.1: n-butyllithium; lithium chloride / tetrahydrofuran; cyclohexane / 0.75 h / -78 °C / Inert atmosphere

4.2: 3 h / -78 °C / Inert atmosphere

4.3: 0.5 h / 60 °C / Inert atmosphere

With 1H-imidazole; methanol; dmap; n-butyllithium; potassium tert-butylate; sodium methylate; lithium chloride; In tetrahydrofuran; cyclohexane; N,N-dimethyl-formamide;

DOI:10.1021/ol103119u

Reference yield:

propargyl 2-deoxy-3,4,6-tri-O-t-butyldimethylsilyl-α-D-galactopyranoside (1055313-02-4) → C41H69NO7SSi3 (1266329-62-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butylate / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

2.1: n-butyllithium; lithium chloride / tetrahydrofuran; cyclohexane / 0.75 h / -78 °C / Inert atmosphere

2.2: 3 h / -78 °C / Inert atmosphere

2.3: 0.5 h / 60 °C / Inert atmosphere

With n-butyllithium; potassium tert-butylate; lithium chloride; In tetrahydrofuran; cyclohexane;

DOI:10.1021/ol103119u

upstream raw materials:

propargyl 2-deoxy-3,4,6-tri-O-t-butyldimethylsilyl-α-D-galactopyranoside

allenyl 2-deoxy-3,4,6-tri-O-t-butyldimethylsilyl-α-D-galactopyranoside

N-(benzylidene)-p-methylbenzenesulfonamide

1,3,4,6-Tetra-O-acetyl-2-desoxy-α/β-D-lyxo-hexopyranose

Downstream raw materials:

C₁₇H₁₇NO₃S

phenyl 3,4,6-tri-O-(t-butyldimethylsilyl)-2-deoxy-1-thio-α-D-lyxo-pyranoside