3-(4-Methylphenyl)quinolin-2-amine

Base Information

• Chemical Name: 3-(4-Methylphenyl)quinolin-2-amine
• CAS No.: 33543-53-2
• Molecular Formula: C₁₆H₁₄N₂
• Molecular Weight: 234.301
• DSSTox Substance ID: DTXSID101322181
• ChEMBL ID: CHEMBL1352881
• Mol file: 33543-53-2.mol

Synonyms:3-(4-methylphenyl)quinolin-2-amine;33543-53-2;3-(4-methylphenyl)-2-quinolinamine;MLS001166009;SCHEMBL1767756;CHEMBL1352881;DTXSID101322181;HMS2878O12;AKOS005096771;SMR000550278;5W-0816

Chemical Property of 3-(4-Methylphenyl)quinolin-2-amine

Chemical Property:

• XLogP3: 3.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 234.115698455
• Heavy Atom Count: 18
• Complexity: 270

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C2=CC3=CC=CC=C3N=C2N

Technology Process of 3-(4-Methylphenyl)quinolin-2-amine

There total 2 articles about 3-(4-Methylphenyl)quinolin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-Aminobenzyl alcohol (5344-90-1) + (4-methylphenyl)acetonitrile (2947-61-7) → 3-(p-tolyl)quinolin-2-amine (33543-53-2)

Guidance literature:

With C₄₁H₄₄ClIrN₂O₄; potassium hydroxide; In toluene; at 135 ℃; for 4h;

DOI:10.1039/d0dt04082g

Reference yield:

→ 3-(p-tolyl)quinolin-2-amine (33543-53-2)

Guidance literature:

2-Aminobenzaldehyd, (4-Tolyl)acetonitril;

upstream raw materials:

2-Aminobenzyl alcohol

(4-methylphenyl)acetonitrile