tert-butoxycarbonylamino-(4-hydroxy-3-iodo-phenyl)-acetic acid methyl ester

Base Information

• Chemical Name: tert-butoxycarbonylamino-(4-hydroxy-3-iodo-phenyl)-acetic acid methyl ester
• CAS No.: 229154-32-9
• Molecular Formula: C₁₄H₁₈INO₅
• Molecular Weight: 407.205

Synonyms:tert-butoxycarbonylamino-(4-hydroxy-3-iodo-phenyl)-acetic acid methyl ester

Chemical Property of tert-butoxycarbonylamino-(4-hydroxy-3-iodo-phenyl)-acetic acid methyl ester

Chemical Property:

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Technology Process of tert-butoxycarbonylamino-(4-hydroxy-3-iodo-phenyl)-acetic acid methyl ester

There total 3 articles about tert-butoxycarbonylamino-(4-hydroxy-3-iodo-phenyl)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

D-4-hydroxyphenylglycine (22818-40-2) → tert-butoxycarbonylamino-(4-hydroxy-3-iodo-phenyl)-acetic acid methyl ester (229154-32-9)

Guidance literature:

Multi-step reaction with 3 steps

1: ICl, HOAc

2: AcCl

3: NaHCO₃ / CH₂Cl₂

With Iodine monochloride; sodium hydrogencarbonate; acetic acid; acetyl chloride; In dichloromethane;

DOI:10.1016/S0040-4039(99)00557-2

Reference yield:

(R)-Amino-(4-hydroxy-3-iodo-phenyl)-acetic acid (229154-30-7) → tert-butoxycarbonylamino-(4-hydroxy-3-iodo-phenyl)-acetic acid methyl ester (229154-32-9)

Guidance literature:

Multi-step reaction with 2 steps

1: AcCl

2: NaHCO₃ / CH₂Cl₂

With sodium hydrogencarbonate; acetyl chloride; In dichloromethane;

DOI:10.1016/S0040-4039(99)00557-2

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + (R)-Amino-(4-hydroxy-3-iodo-phenyl)-acetic acid methyl ester (229154-31-8) → tert-butoxycarbonylamino-(4-hydroxy-3-iodo-phenyl)-acetic acid methyl ester (229154-32-9)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; Yield given;

DOI:10.1016/S0040-4039(99)00557-2

upstream raw materials:

di-tert-butyl dicarbonate

(R)-Amino-(4-hydroxy-3-iodo-phenyl)-acetic acid methyl ester

D-4-hydroxyphenylglycine

(R)-Amino-(4-hydroxy-3-iodo-phenyl)-acetic acid

Downstream raw materials:

C₅₀H₆₂I₂N₂O₁₀

4-{4-[3-benzyloxy-1-benzyloxymethyl-2-(tert-butyl-dimethyl-silanyloxy)-propoxy]-3-iodo-phenyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

(R)-4-[4-((1R,2S)-3-Benzyloxy-1-benzyloxymethyl-2-hydroxy-propoxy)-3-iodo-phenyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

4-(4-hydroxy-3-iodo-phenyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

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