(3S,5S,8R,10S)-3-benzyloxycarbonylamino-8-hydroxy-10-triethylsilyloxy-1-oxaspiro[4,5]dec-6-en-2-one

Base Information

Chemical Name:(3S,5S,8R,10S)-3-benzyloxycarbonylamino-8-hydroxy-10-triethylsilyloxy-1-oxaspiro[4,5]dec-6-en-2-one
CAS No.:942618-33-9
Molecular Formula:C₂₃H₃₃NO₆Si
Molecular Weight:447.604
Hs Code.:

Synonyms:(3S,5S,8R,10S)-3-benzyloxycarbonylamino-8-hydroxy-10-triethylsilyloxy-1-oxaspiro[4,5]dec-6-en-2-one

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Chemical Property of (3S,5S,8R,10S)-3-benzyloxycarbonylamino-8-hydroxy-10-triethylsilyloxy-1-oxaspiro[4,5]dec-6-en-2-one

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Technology Process of (3S,5S,8R,10S)-3-benzyloxycarbonylamino-8-hydroxy-10-triethylsilyloxy-1-oxaspiro[4,5]dec-6-en-2-one

There total 6 articles about (3S,5S,8R,10S)-3-benzyloxycarbonylamino-8-hydroxy-10-triethylsilyloxy-1-oxaspiro[4,5]dec-6-en-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 942618-32-8
(3S,5S,10S)-3-benzyloxycarbonylamino-10-triethylsilyloxy-1-oxaspiro[4,5]dec-6-ene-2,8-dione

: 942618-33-9
(3S,5S,8R,10S)-3-benzyloxycarbonylamino-8-hydroxy-10-triethylsilyloxy-1-oxaspiro[4,5]dec-6-en-2-one

Guidance literature:: With sodium tetrahydroborate; cerium(III) chloride; In tetrahydrofuran; isopropyl alcohol; at 0 ℃; for 0.666667h;
DOI:10.1021/jo070337k

Reference yield:

: 942618-30-6
(4S)-4-benzyloxycarbonylamino-6',7'-epoxy-1',3,4,4',4'a,8'a-hexahydrospiro[furan-2(5H),5'(8'H)-1',4'-methanonaphthalene]-5',8'-dione

: 942618-33-9
(3S,5S,8R,10S)-3-benzyloxycarbonylamino-8-hydroxy-10-triethylsilyloxy-1-oxaspiro[4,5]dec-6-en-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / SmI₂ / methanol; tetrahydrofuran / 1 h / 78 °C

2: 100 percent / imidazole / CH₂Cl₂ / 14 h / 20 °C

3: 100 percent / maleic anhydride / diphenyl ether / 1 h / 230 °C

4: 95 percent / NaBH₄; CeCl₃*7H₂O / propan-2-ol; tetrahydrofuran / 0.67 h / 0 °C

With 1H-imidazole; maleic anhydride; sodium tetrahydroborate; samarium diiodide; cerium(III) chloride; In tetrahydrofuran; methanol; diphenylether; dichloromethane; isopropyl alcohol;
DOI:10.1021/jo070337k

Reference yield:

: 942618-57-7
C₂₂H₂₃NO₆

: 942618-33-9
(3S,5S,8R,10S)-3-benzyloxycarbonylamino-8-hydroxy-10-triethylsilyloxy-1-oxaspiro[4,5]dec-6-en-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / imidazole / CH₂Cl₂ / 14 h / 20 °C

2: 100 percent / maleic anhydride / diphenyl ether / 1 h / 230 °C

3: 95 percent / NaBH₄; CeCl₃*7H₂O / propan-2-ol; tetrahydrofuran / 0.67 h / 0 °C

With 1H-imidazole; maleic anhydride; sodium tetrahydroborate; cerium(III) chloride; In tetrahydrofuran; diphenylether; dichloromethane; isopropyl alcohol;
DOI:10.1021/jo070337k