4-amino-(6-(1-(6-fluoro-4-((2-methoxyethyl)amino)-3-phenyl-2-quinolinyl)ethyl)amino)-5-pyrimidinecarbonitrile

Base Information

Chemical Name:4-amino-(6-(1-(6-fluoro-4-((2-methoxyethyl)amino)-3-phenyl-2-quinolinyl)ethyl)amino)-5-pyrimidinecarbonitrile
CAS No.:1259521-79-3
Molecular Formula:C₂₅H₂₄FN₇O
Molecular Weight:457.51
Hs Code.:

Synonyms:4-amino-(6-(1-(6-fluoro-4-((2-methoxyethyl)amino)-3-phenyl-2-quinolinyl)ethyl)amino)-5-pyrimidinecarbonitrile

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Chemical Property of 4-amino-(6-(1-(6-fluoro-4-((2-methoxyethyl)amino)-3-phenyl-2-quinolinyl)ethyl)amino)-5-pyrimidinecarbonitrile

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Technology Process of 4-amino-(6-(1-(6-fluoro-4-((2-methoxyethyl)amino)-3-phenyl-2-quinolinyl)ethyl)amino)-5-pyrimidinecarbonitrile

There total 10 articles about 4-amino-(6-(1-(6-fluoro-4-((2-methoxyethyl)amino)-3-phenyl-2-quinolinyl)ethyl)amino)-5-pyrimidinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1259521-80-6
2-(1-aminoethyl)-6-fluoro-N-(2-methoxyethyl)-3-phenylquinolin-4-amine

: 60025-09-4
4-amino-6-chloropyrimidine-5-carbonitrile

: 1259521-79-3
4-amino-(6-(1-(6-fluoro-4-((2-methoxyethyl)amino)-3-phenyl-2-quinolinyl)ethyl)amino)-5-pyrimidinecarbonitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In butan-1-ol; at 110 ℃;

Reference yield:

: 1259521-34-0
4-chloro-2-ethyl-6-fluoro-3-phenylquinoline

: 1259521-79-3
4-amino-(6-(1-(6-fluoro-4-((2-methoxyethyl)amino)-3-phenyl-2-quinolinyl)ethyl)amino)-5-pyrimidinecarbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 3 h / Reflux

2: N,N-dimethyl-formamide / 16 h / 60 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 3 h / 100 °C

4: hydrazine / ethanol / 0.5 h / 60 °C

5: butan-1-ol / 16 h / 100 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; hydrazine; dibenzoyl peroxide; In tetrachloromethane; ethanol; N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1016/j.bmcl.2015.01.001

Reference yield:

: 1259521-32-8
ethyl 3-(4-fluorophenylamino)-3-oxo-2-phenylpropanoate

: 1259521-79-3
4-amino-(6-(1-(6-fluoro-4-((2-methoxyethyl)amino)-3-phenyl-2-quinolinyl)ethyl)amino)-5-pyrimidinecarbonitrile

Guidance literature:: Multi-step reaction with 9 steps

1: lithium hydroxide / tetrahydrofuran / 2 h

2: polyphosphoric acid / 2 h / 130 °C

3: trichlorophosphate / 2 h / 100 °C

4: potassium carbonate; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex / tetrahydrofuran / 6 h / Reflux

5: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 3 h / Reflux

6: N,N-dimethyl-formamide / 16 h / 60 °C

7: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / 3 h / 100 °C

8: hydrazine / ethanol / 0.5 h / 60 °C

9: butan-1-ol / 16 h / 100 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; lithium hydroxide; sodium t-butanolate; hydrazine; trichlorophosphate; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; ethanol; N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1016/j.bmcl.2015.01.001