methyl 2-(4-bromo-2-fluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)acetate

Base Information

Chemical Name:methyl 2-(4-bromo-2-fluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)acetate
CAS No.:1426050-39-6
Molecular Formula:C₂₀H₂₄BrFN₂O₄
Molecular Weight:455.324
Hs Code.:

Synonyms:methyl 2-(4-bromo-2-fluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)acetate

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Chemical Property of methyl 2-(4-bromo-2-fluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)acetate

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Technology Process of methyl 2-(4-bromo-2-fluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)acetate

There total 8 articles about methyl 2-(4-bromo-2-fluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1426050-38-5
methyl 2-bromo-2-(4-bromo-2-fluorophenyl)acetate

: 1375107-47-3
4-cyclopropyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one hydrochloride

: 1426050-39-6
methyl 2-(4-bromo-2-fluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

Reference yield:

: 76283-09-5
4-bromo-2-fluorobenzyl bromide

: 1426050-39-6
methyl 2-(4-bromo-2-fluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol; water / 72 h / Reflux

1.2: 1 h

2.1: sulfuric acid / 72 h / 80 °C

3.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 80 °C / Inert atmosphere

4.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; potassium carbonate; In tetrachloromethane; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1375107-45-1
1,1-dimethylethyl-4-{[(chloroacetyl)(cyclopropyl)amino]methyl}-4-hydroxy-1-piperidine carboxylate

: 1426050-39-6
methyl 2-(4-bromo-2-fluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; sodium hydroxide / tetrahydrofuran; water

2: hydrogenchloride; ethanol / 1,4-dioxane / 20 °C / Cooling with ice

3: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C

With hydrogenchloride; ethanol; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;