C₅₀H₈₅IO₆Si₂

Base Information

Chemical Name:C₅₀H₈₅IO₆Si₂
CAS No.:1082395-54-7
Molecular Formula:C₅₀H₈₅IO₆Si₂
Molecular Weight:965.297
Hs Code.:

C<sub>50</sub>H<sub>85</sub>IO<sub>6</sub>Si<sub>2</sub>

Synonyms:C₅₀H₈₅IO₆Si₂

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Chemical Property of C₅₀H₈₅IO₆Si₂

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Technology Process of C₅₀H₈₅IO₆Si₂

There total 1 articles about C₅₀H₈₅IO₆Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 939383-45-6
C₂₀H₂₄F₆IO₆P

: 373645-86-4
(5Z,13Z)-(2R,3R,4S,8S,9R,10R,11S,12S)-3,9-bis(tertbutyldimethylsilanyloxy)-11-hydroxy-2,4,6,8,10,12-hexamethylhexadeca-5,13,15-trienal

: 1082395-54-7
C₅₀H₈₅IO₆Si₂

: 1268722-10-6
C₅₀H₈₅IO₆Si₂

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; 18-crown-6 ether; potassium carbonate; In toluene; at 0 ℃; for 421h; optical yield given as %de;
DOI:10.1002/asia.201000541

Reference yield:

: 1082395-54-7
C₅₀H₈₅IO₆Si₂

: 1207166-58-2
3-benzoylamino-3-phenyl-2-triethylsilanyloxy-propionic acid 14,20-bis(tert-butyl-dimethyl-silanyloxy)-8-methoxy-7,13,15,17,19,21-hexamethyl-22-(1-methyl-penta-2,4-dienyl)-2-oxo-oxacyclodocosa-3,5,11,16-tetraen-10-yl ester

Guidance literature:: Multi-step reaction with 11 steps

1.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 2.5 h / 0 °C / pH 7 / aq. buffer

2.1: borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene / 4 h / -30 °C

3.1: pyridinium p-toluenesulfonate / dichloromethane / 0 - 20 °C

4.1: copper(I) thiophene-2-carboxylate / 1-methyl-pyrrolidin-2-one / 16 h / 20 °C

5.1: methanol; potassium fluoride / tetrahydrofuran / 2 h / 20 °C

6.1: 2,4,6-trichlorobenzoyl chloride; triethylamine / toluene / 20 °C

6.2: 0.33 h / 20 °C

7.1: pyridinium p-toluenesulfonate / methanol; dichloromethane / 0 - 20 °C

8.1: 2,6-dimethylpyridine / dichloromethane / -98 - 20 °C

9.1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 0.17 h / 20 °C

9.2: 1.5 h / 20 °C

10.1: pyridinium p-toluenesulfonate / methanol; dichloromethane / 2.08 h / 0 - 20 °C

11.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.17 h / -78 °C

11.2: -78 - 0 °C

With 2,6-dimethylpyridine; methanol; potassium fluoride; borane-THF; copper(I) thiophene-2-carboxylate; 2,4,6-trichlorobenzoyl chloride; sodium hexamethyldisilazane; pyridinium p-toluenesulfonate; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; toluene; 4.1: Stille-Liebeskind cross coupling / 6.1: Yamaguchi macrolactonization / 6.2: Yamaguchi macrolactonization;
DOI:10.1002/asia.201000541

Reference yield:

: 1082395-54-7
C₅₀H₈₅IO₆Si₂

: 1207166-48-0
3-benzoylamino-2-hydroxy-3-phenyl-propionic acid 14,20-dihydroxy-8-methoxy-7,13,15,17,19,21-hexamethyl-22-(1-methyl-penta-2,4-dienyl)-2-oxo-oxacyclodocosa-3,5,11,16-tetraen-10-yl ester

Guidance literature:: Multi-step reaction with 12 steps

1.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 2.5 h / 0 °C / pH 7 / aq. buffer

2.1: borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene / 4 h / -30 °C

3.1: pyridinium p-toluenesulfonate / dichloromethane / 0 - 20 °C

4.1: copper(I) thiophene-2-carboxylate / 1-methyl-pyrrolidin-2-one / 16 h / 20 °C

5.1: methanol; potassium fluoride / tetrahydrofuran / 2 h / 20 °C

6.1: 2,4,6-trichlorobenzoyl chloride; triethylamine / toluene / 20 °C

6.2: 0.33 h / 20 °C

7.1: pyridinium p-toluenesulfonate / methanol; dichloromethane / 0 - 20 °C

8.1: 2,6-dimethylpyridine / dichloromethane / -98 - 20 °C

9.1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 0.17 h / 20 °C

9.2: 1.5 h / 20 °C

10.1: pyridinium p-toluenesulfonate / methanol; dichloromethane / 2.08 h / 0 - 20 °C

11.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.17 h / -78 °C

11.2: -78 - 0 °C

12.1: pyridine hydrogenfluoride / tetrahydrofuran; pyridine / 0 - 20 °C

With 2,6-dimethylpyridine; methanol; potassium fluoride; borane-THF; copper(I) thiophene-2-carboxylate; 2,4,6-trichlorobenzoyl chloride; sodium hexamethyldisilazane; pyridinium p-toluenesulfonate; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; pyridine hydrogenfluoride; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; pyridine; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; toluene; 4.1: Stille-Liebeskind cross coupling / 6.1: Yamaguchi macrolactonization / 6.2: Yamaguchi macrolactonization;
DOI:10.1002/asia.201000541