N-(4-methyl-3-(5-methyl-4-(6-(2-morpholin-4-ylethylamino)pyrimidin-4-yl)-2H-pyrazol-3-ylamino)-phenyl)-3-trifluoromethylbenzamide

Base Information

Chemical Name:N-(4-methyl-3-(5-methyl-4-(6-(2-morpholin-4-ylethylamino)pyrimidin-4-yl)-2H-pyrazol-3-ylamino)-phenyl)-3-trifluoromethylbenzamide
CAS No.:1018467-34-9
Molecular Formula:C₂₉H₃₁F₃N₈O₂
Molecular Weight:580.613
Hs Code.:

Synonyms:N-(4-methyl-3-(5-methyl-4-(6-(2-morpholin-4-ylethylamino)pyrimidin-4-yl)-2H-pyrazol-3-ylamino)-phenyl)-3-trifluoromethylbenzamide

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Chemical Property of N-(4-methyl-3-(5-methyl-4-(6-(2-morpholin-4-ylethylamino)pyrimidin-4-yl)-2H-pyrazol-3-ylamino)-phenyl)-3-trifluoromethylbenzamide

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Technology Process of N-(4-methyl-3-(5-methyl-4-(6-(2-morpholin-4-ylethylamino)pyrimidin-4-yl)-2H-pyrazol-3-ylamino)-phenyl)-3-trifluoromethylbenzamide

There total 3 articles about N-(4-methyl-3-(5-methyl-4-(6-(2-morpholin-4-ylethylamino)pyrimidin-4-yl)-2H-pyrazol-3-ylamino)-phenyl)-3-trifluoromethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2038-03-1
4-(2-AMINOETHYL)MORPHOLINE

: 1018473-16-9
N-(3-(2-(6-methanesulfinylpyrimidin-4-yl)-5-methyl-2H-pyrazol-3-ylamino)-4-methylphenyl)-3-trifluoromethylbenzamide

: 1018467-34-9
N-(4-methyl-3-(5-methyl-4-(6-(2-morpholin-4-ylethylamino)pyrimidin-4-yl)-2H-pyrazol-3-ylamino)-phenyl)-3-trifluoromethylbenzamide

Guidance literature:: In isopropyl alcohol; at 80 ℃; for 3h;

Reference yield:

: 1018473-15-8
5-methyl-2-(6-methylsulfanylpyrimidin-4-yl)-2H-pyrazol-3-ylamine

: 1018467-34-9
N-(4-methyl-3-(5-methyl-4-(6-(2-morpholin-4-ylethylamino)pyrimidin-4-yl)-2H-pyrazol-3-ylamino)-phenyl)-3-trifluoromethylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.5 h / 150 °C / Irradiation

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C

3: isopropyl alcohol / 3 h / 80 °C

With caesium carbonate; 3-chloro-benzenecarboperoxoic acid; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane; isopropyl alcohol;

Reference yield:

: 1018467-70-3
N-(4-methyl-3-(5-methyl-2-(6-methylsulfanylpyrimidin-4-yl)-2H-pyrazol-3-ylamino)-phenyl)-3-trifluoromethylbenzamide

: 1018467-34-9
N-(4-methyl-3-(5-methyl-4-(6-(2-morpholin-4-ylethylamino)pyrimidin-4-yl)-2H-pyrazol-3-ylamino)-phenyl)-3-trifluoromethylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C

2: isopropyl alcohol / 3 h / 80 °C

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; isopropyl alcohol;