<2S-<2R^*,4*,(R^*)>>>-phenylmethyl 2-<<<3-methyl-1-<<3-(2-methylpropyl)-5-oxo-1-piperazinyl>methyl>butyl>amino>carbonyl>-1-pyrrolidinecarboxylate

Base Information

• Chemical Name: <2S-<2R^*,4*,(R^*)>>>-phenylmethyl 2-<<<3-methyl-1-<<3-(2-methylpropyl)-5-oxo-1-piperazinyl>methyl>butyl>amino>carbonyl>-1-pyrrolidinecarboxylate
• CAS No.: 101399-25-1
• Molecular Formula: C₂₇H₄₂N₄O₄
• Molecular Weight: 486.655

Synonyms:<2S-<2R^*,4*,(R^*)>>>-phenylmethyl 2-<<<3-methyl-1-<<3-(2-methylpropyl)-5-oxo-1-piperazinyl>methyl>butyl>amino>carbonyl>-1-pyrrolidinecarboxylate

Chemical Property of <2S-<2R^*,4*,(R^*)>>>-phenylmethyl 2-<<<3-methyl-1-<<3-(2-methylpropyl)-5-oxo-1-piperazinyl>methyl>butyl>amino>carbonyl>-1-pyrrolidinecarboxylate

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Technology Process of <2S-<2R^*,4*,(R^*)>>>-phenylmethyl 2-<<<3-methyl-1-<<3-(2-methylpropyl)-5-oxo-1-piperazinyl>methyl>butyl>amino>carbonyl>-1-pyrrolidinecarboxylate

There total 2 articles about <2S-<2R^*,4*,(R^*)>>>-phenylmethyl 2-<<<3-methyl-1-<<3-(2-methylpropyl)-5-oxo-1-piperazinyl>methyl>butyl>amino>carbonyl>-1-pyrrolidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

*,R*)>-1,1-dimethylethyl N,N-bis<4-methyl-2-<<(phenylmethoxy)carbonyl>amino>pentyl>glycinate (101250-57-1) → <2S-<2R*,4*,(R*)>>>-phenylmethyl 2-<<<3-methyl-1-<<3-(2-methylpropyl)-5-oxo-1-piperazinyl>methyl>butyl>amino>carbonyl>-1-pyrrolidinecarboxylate (101399-25-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / H₂ / 20percent Pd/C / methanol

2: 1H-benzotriazol-1-ol (HOBT), DCC / tetrahydrofuran

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1021/jm00156a012

Reference yield:

*,R*)>-4-(2-amino-4-methylpentyl)-6-(2-methylpropyl)-2-piperazinone (101250-39-9) + N-Benzyloxycarbonyl-L-proline (1148-11-4) → <2S-<2R*,4*,(R*)>>>-phenylmethyl 2-<<<3-methyl-1-<<3-(2-methylpropyl)-5-oxo-1-piperazinyl>methyl>butyl>amino>carbonyl>-1-pyrrolidinecarboxylate (101399-25-1)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran;

DOI:10.1021/jm00156a012

upstream raw materials:

*,R^*)>-4-(2-amino-4-methylpentyl)-6-(2-methylpropyl)-2-piperazinone

N-Benzyloxycarbonyl-L-proline

*,R^*)>-1,1-dimethylethyl N,N-bis<4-methyl-2-<<(phenylmethoxy)carbonyl>amino>pentyl>glycinate

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