5,7-Dimethoxy-2-methyl-chromen-4-one

Base Information

• Chemical Name: 5,7-Dimethoxy-2-methyl-chromen-4-one
• CAS No.: 26213-83-2
• Molecular Formula: C12H12 O4
• Molecular Weight: 220.22128
• Hs Code.: 2914509090
• ChEMBL ID: CHEMBL449227
• DSSTox Substance ID: DTXSID80566578
• Nikkaji Number: J345.876H
• Wikidata: Q82452250
• Mol file: 26213-83-2.mol

Synonyms:26213-83-2;5,7-Dimethoxy-2-methyl-chromen-4-one;5,7-dimethoxy-2-methyl-4H-chromen-4-one;CHEMBL449227;SCHEMBL8833383;5,7-dimethoxy-2-methylchromone;DTXSID80566578;MFCD00599372;AKOS015965633;AC-20778;SY310744;5,7-Dimethoxy-2-methyl-4H-1-benzopyran-4-one

Chemical Property of 5,7-Dimethoxy-2-methyl-chromen-4-one

Chemical Property:

• Vapor Pressure: 6.07E-06mmHg at 25°C
• Refractive Index: 1.544
• Boiling Point: 378.9°C at 760 mmHg
• Flash Point: 170.4°C
• PSA: 48.67000
• Density: 1.202g/cm³
• LogP: 2.11860
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 220.07355886
• Heavy Atom Count: 16
• Complexity: 310

Purity/Quality:

99% ^*data from raw suppliers

5,7-DIMETHOXY-2-METHYL-CHROMEN-4-ONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=O)C2=C(O1)C=C(C=C2OC)OC

Technology Process of 5,7-Dimethoxy-2-methyl-chromen-4-one

There total 7 articles about 5,7-Dimethoxy-2-methyl-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

3,5-dimethoxyphenol (500-99-2) + 5-(1-methoxyethylene) Meldrum's acid (121781-82-6) → 2-(ethoxymethyl)-5, 7-dimethoxy-4H-chromen-4-one (26213-83-2)

Guidance literature:

With ytterbium(III) triflate; In nitromethane; at 100 ℃; for 1.5h;

DOI:10.1021/jo052000t

Reference yield: 72.0%

eugenin (1013-69-0) + dimethyl sulfate (77-78-1) → 2-(ethoxymethyl)-5, 7-dimethoxy-4H-chromen-4-one (26213-83-2)

Guidance literature:

With potassium carbonate; In acetone; for 4h; Reflux;

DOI:10.1021/jo502571r

Reference yield: 50.0%

1-(2-hydroxy-4, 6-dimethoxyphenyl)butane-1,3-dione (65547-60-6) → 2-(ethoxymethyl)-5, 7-dimethoxy-4H-chromen-4-one (26213-83-2)

Guidance literature:

With hydrogenchloride; acetic acid; In water; at 70 ℃; for 0.5h;

DOI:10.1016/j.bmcl.2012.08.071

upstream raw materials:

1-(2-hydroxy-4, 6-dimethoxyphenyl)butane-1,3-dione

1-Methyl-3-(2',4',6'-trimethoxyphenyl)propan-1,3-dione

3,5-dimethoxyphenol

5-(1-methoxyethylene) Meldrum's acid

Downstream raw materials:

eugenin

5,7-dimethoxy-2-[2-(4-trifluoromethoxyphenyl)vinyl]chromen-4-one

2-[2-(3,5-dimethoxyphenyl)vinyl]-5,7-dimethoxychromen-4-one

2-[2-(4-fluorophenyl)vinyl]-5,7-dimethoxychromen-4-one