2,6-diamino-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-ribofuranosyl)purine

Base Information

Chemical Name:2,6-diamino-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-ribofuranosyl)purine
CAS No.:156357-14-1
Molecular Formula:C₂₄H₂₁FN₆O₅
Molecular Weight:492.466
Hs Code.:

Synonyms:2,6-diamino-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-ribofuranosyl)purine

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Chemical Property of 2,6-diamino-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-ribofuranosyl)purine

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Technology Process of 2,6-diamino-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-ribofuranosyl)purine

There total 6 articles about 2,6-diamino-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-ribofuranosyl)purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 156357-13-0
2,6-diazido-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-ribofuranosyl)purine

: 156357-14-1
2,6-diamino-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-ribofuranosyl)purine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; N,N-dimethyl acetamide; for 20h; Ambient temperature;
DOI:10.1080/15257779408013243

Reference yield:

: 149623-91-6
1-O-acetyl-3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-ribofuranoside

: 156357-14-1
2,6-diamino-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-ribofuranosyl)purine

Guidance literature:: Multi-step reaction with 3 steps

1: 23 percent / p-TsOH / 0.83 h / 160 °C / 25 Torr

2: 75 percent / NaN₃ / ethanol; H₂O / 1.) reflux, 1 h, 2.) room temperature, 20 h

3: 94 percent / H₂ / Pd on carbon / ethanol; N,N-dimethyl-acetamide / 20 h / Ambient temperature

With sodium azide; hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In ethanol; N,N-dimethyl acetamide; water;
DOI:10.1080/15257779408013243

Reference yield:

: 3,5-di-O-benzoyl-2-deoxy-2-fluoro-D-ribofuranose

: 156357-14-1
2,6-diamino-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-ribofuranosyl)purine

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / pyridine / 20 h / Ambient temperature

2: 23 percent / p-TsOH / 0.83 h / 160 °C / 25 Torr

3: 75 percent / NaN₃ / ethanol; H₂O / 1.) reflux, 1 h, 2.) room temperature, 20 h

4: 94 percent / H₂ / Pd on carbon / ethanol; N,N-dimethyl-acetamide / 20 h / Ambient temperature

With pyridine; sodium azide; hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In ethanol; N,N-dimethyl acetamide; water;
DOI:10.1080/15257779408013243