1-(3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)allyl)piperazin-2-one

Base Information

Chemical Name:1-(3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)allyl)piperazin-2-one
CAS No.:1401729-11-0
Molecular Formula:C₂₄H₂₉N₅O
Molecular Weight:403.527
Hs Code.:

Synonyms:1-(3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)allyl)piperazin-2-one

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Chemical Property of 1-(3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)allyl)piperazin-2-one

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Technology Process of 1-(3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)allyl)piperazin-2-one

There total 5 articles about 1-(3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)allyl)piperazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: C₂₉H₃₇N₅O₃

: 1401729-11-0
1-(3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)allyl)piperazin-2-one

Guidance literature:: With hydrogenchloride; In ethanol; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.6b01703

Reference yield:

: 57775-08-3
3-(4-Bromo-phenyl)-propionitrile

: 1401729-11-0
1-(3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)allyl)piperazin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium 2-methylbutan-2-olate / tetrahydrofuran; toluene / 0.33 h / 20 °C / Inert atmosphere

2.1: hydrazine hydrate; acetic acid / ethanol / 0.25 h / 140 °C / Inert atmosphere; Microwave irradiation

2.2: 0.5 h / 160 °C / Inert atmosphere; Microwave irradiation

3.1: trifluoroacetic acid / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere

4.1: N-Methyldicyclohexylamine; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 0.25 h / 140 °C / Inert atmosphere; Microwave irradiation

5.1: hydrogenchloride / ethanol / 2 h / 20 °C / Inert atmosphere

With hydrogenchloride; bis(tri-t-butylphosphine)palladium⁽⁰⁾; hydrazine hydrate; N-Methyldicyclohexylamine; potassium 2-methylbutan-2-olate; acetic acid; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; toluene; 4.1: |Heck Reaction;
DOI:10.1021/acs.jmedchem.6b01703

Reference yield:

: 1401728-62-8
4-(4-bromobenzyl)-5-ethyl-2H-pyrazol-3-ylamine

: 1401729-11-0
1-(3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)allyl)piperazin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere

2: N-Methyldicyclohexylamine; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 0.25 h / 140 °C / Inert atmosphere; Microwave irradiation

3: hydrogenchloride / ethanol / 2 h / 20 °C / Inert atmosphere

With hydrogenchloride; bis(tri-t-butylphosphine)palladium⁽⁰⁾; N-Methyldicyclohexylamine; trifluoroacetic acid; In 1,4-dioxane; ethanol; 2: |Heck Reaction;
DOI:10.1021/acs.jmedchem.6b01703