2-(biphenyl-4-yl)-7-(4-methoxyphenyl)-4-phenyl-7H-pyrrolo[2,3-d]pyrimidine

Base Information

Chemical Name:2-(biphenyl-4-yl)-7-(4-methoxyphenyl)-4-phenyl-7H-pyrrolo[2,3-d]pyrimidine
CAS No.:1334106-90-9
Molecular Formula:C₃₁H₂₃N₃O
Molecular Weight:453.543
Hs Code.:

Synonyms:2-(biphenyl-4-yl)-7-(4-methoxyphenyl)-4-phenyl-7H-pyrrolo[2,3-d]pyrimidine

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Chemical Property of 2-(biphenyl-4-yl)-7-(4-methoxyphenyl)-4-phenyl-7H-pyrrolo[2,3-d]pyrimidine

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Technology Process of 2-(biphenyl-4-yl)-7-(4-methoxyphenyl)-4-phenyl-7H-pyrrolo[2,3-d]pyrimidine

There total 6 articles about 2-(biphenyl-4-yl)-7-(4-methoxyphenyl)-4-phenyl-7H-pyrrolo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 696-62-8
para-iodoanisole

: 1334106-86-3
2-(biphenyl-4-yl)-4-phenyl-7H-pyrrolo[2,3-d]pyrimidine

: 1334106-90-9
2-(biphenyl-4-yl)-7-(4-methoxyphenyl)-4-phenyl-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: 2-(biphenyl-4-yl)-4-phenyl-7H-pyrrolo[2,3-d]pyrimidine; With potassium phosphate; copper(l) iodide; In 1,4-dioxane; Inert atmosphere;

para-iodoanisole; With trans-1,2-Diaminocyclohexane; In 1,4-dioxane; for 11h; Inert atmosphere; Reflux;
DOI:10.1055/s-0030-1260931

Reference yield:

: 1236078-07-1
2-chloro-4-phenyl-7H-pyrrolo[2,3-d]pyrimidine

: 1334106-90-9
2-(biphenyl-4-yl)-7-(4-methoxyphenyl)-4-phenyl-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 1.33 h / Reflux

2.1: palladium diacetate; CyJohnPhos / 1,4-dioxane / Inert atmosphere

2.2: Reflux; Inert atmosphere

3.1: hydrogenchloride / water; acetone / Reflux

4.1: copper(l) iodide; potassium phosphate / 1,4-dioxane / Inert atmosphere

4.2: 11 h / Inert atmosphere; Reflux

With hydrogenchloride; dmap; potassium phosphate; copper(l) iodide; palladium diacetate; N-ethyl-N,N-diisopropylamine; CyJohnPhos; In 1,4-dioxane; dichloromethane; water; acetone; 2.1: Suzuki coupling / 2.2: Suzuki coupling;
DOI:10.1055/s-0030-1260931

Reference yield:

: 1334106-80-7
tert-butyl 2-chloro-4-phenyl-7H-pyrrolo[2,3-d]pyrimidine-7-carboxylate

: 1334106-90-9
2-(biphenyl-4-yl)-7-(4-methoxyphenyl)-4-phenyl-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium diacetate; CyJohnPhos / 1,4-dioxane / Inert atmosphere

1.2: Reflux; Inert atmosphere

2.1: hydrogenchloride / water; acetone / Reflux

3.1: copper(l) iodide; potassium phosphate / 1,4-dioxane / Inert atmosphere

3.2: 11 h / Inert atmosphere; Reflux

With hydrogenchloride; potassium phosphate; copper(l) iodide; palladium diacetate; CyJohnPhos; In 1,4-dioxane; water; acetone; 1.1: Suzuki coupling / 1.2: Suzuki coupling;
DOI:10.1055/s-0030-1260931