methyl 1-methyl-2,3-diphenyl-1H-indole-5-carboxylate

Base Information

• Chemical Name: methyl 1-methyl-2,3-diphenyl-1H-indole-5-carboxylate
• CAS No.: 868540-96-9
• Molecular Formula: C₂₃H₁₉NO₂
• Molecular Weight: 341.409
• Mol file: 868540-96-9.mol

Synonyms:methyl 1-methyl-2,3-diphenyl-1H-indole-5-carboxylate

Chemical Property of methyl 1-methyl-2,3-diphenyl-1H-indole-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 1-methyl-2,3-diphenyl-1H-indole-5-carboxylate

There total 4 articles about methyl 1-methyl-2,3-diphenyl-1H-indole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methyl N-methyl-N-nitroso-4-aminobenzoate (18600-49-2) + diphenyl acetylene (501-65-5) → methyl 1-methyl-2,3-diphenyl-1H-indole-5-carboxylate (868540-96-9)

Guidance literature:

With [Cp*Rh(OAc)2]; In methanol; at 90 ℃; Sealed tube;

DOI:10.1021/ol402523x

Reference yield: 76.0%

methyl N-methyl-N-nitroso-4-aminobenzoate (18600-49-2) + diphenylcyclopropenone (886-38-4) → methyl 1-methyl-2,3-diphenyl-1H-indole-5-carboxylate (868540-96-9)

Guidance literature:

With silver hexafluoroantimonate; chloro(1,5-cyclooctadiene)rhodium(I) dimer; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; In dichloromethane; at 120 ℃; for 36h; Molecular sieve; Sealed tube;

DOI:10.1039/c9cc08926h

Reference yield:

methyl 4-(N-methyl)aminobenzoate (18358-63-9) → methyl 1-methyl-2,3-diphenyl-1H-indole-5-carboxylate (868540-96-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / acetonitrile; water / 0 °C

2: [Cp*Rh(OAc)2] / methanol / 90 °C / Sealed tube

With hydrogenchloride; [Cp*Rh(OAc)2]; In methanol; water; acetonitrile;

DOI:10.1021/ol402523x

upstream raw materials:

methyl N-methyl-N-nitroso-4-aminobenzoate

diphenyl acetylene

methyl 4-(N-methyl)aminobenzoate

diphenylcyclopropenone