N-{4-(3-bromophenyl)-3-cyano-6-[5-(morpholin-4-yl)thiophen-2-yl]pyridin-2-yl}formamidine

Base Information

Chemical Name:N-{4-(3-bromophenyl)-3-cyano-6-[5-(morpholin-4-yl)thiophen-2-yl]pyridin-2-yl}formamidine
CAS No.:856014-37-4
Molecular Formula:C₂₁H₁₈BrN₅OS
Molecular Weight:468.377
Hs Code.:

Synonyms:N-{4-(3-bromophenyl)-3-cyano-6-[5-(morpholin-4-yl)thiophen-2-yl]pyridin-2-yl}formamidine

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Chemical Property of N-{4-(3-bromophenyl)-3-cyano-6-[5-(morpholin-4-yl)thiophen-2-yl]pyridin-2-yl}formamidine

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Technology Process of N-{4-(3-bromophenyl)-3-cyano-6-[5-(morpholin-4-yl)thiophen-2-yl]pyridin-2-yl}formamidine

There total 3 articles about N-{4-(3-bromophenyl)-3-cyano-6-[5-(morpholin-4-yl)thiophen-2-yl]pyridin-2-yl}formamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 856014-36-3
2-amino-4-(3-bromophenyl)-6-[5-(morpholin-4-yl)thiophen-2-yl]nicotinonitrile

: 122-51-0
orthoformic acid triethyl ester

: 856014-37-4
N-{4-(3-bromophenyl)-3-cyano-6-[5-(morpholin-4-yl)thiophen-2-yl]pyridin-2-yl}formamidine

Guidance literature:: 2-amino-4-(3-bromophenyl)-6-[5-(morpholin-4-yl)thiophen-2-yl]nicotinonitrile; orthoformic acid triethyl ester; With ammonium sulfate; Heating;

With ammonia; In ethanol; at 20 ℃;
DOI:10.1016/j.bmc.2005.03.023

Reference yield:

: 5370-25-2
2-Acetyl-5-bromothiophene

: 856014-37-4
N-{4-(3-bromophenyl)-3-cyano-6-[5-(morpholin-4-yl)thiophen-2-yl]pyridin-2-yl}formamidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 68 percent / 145 °C

2.1: 38 percent / ammonium acetate / 1,2-dichloro-ethane / Heating

3.1: ammonium sulfate / Heating

3.2: 93 percent / NH₃ / ethanol / 20 °C

With ammonium acetate; ammonium sulfate; In 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2005.03.023

Reference yield:

: 230972-02-8
1-[5-(4-morpholinyl)-2-thienyl]ethanone

: 856014-37-4
N-{4-(3-bromophenyl)-3-cyano-6-[5-(morpholin-4-yl)thiophen-2-yl]pyridin-2-yl}formamidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 38 percent / ammonium acetate / 1,2-dichloro-ethane / Heating

2.1: ammonium sulfate / Heating

2.2: 93 percent / NH₃ / ethanol / 20 °C

With ammonium acetate; ammonium sulfate; In 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2005.03.023