Technology Process of [(5R)-5-methylundecyl](phenyl)sulfone
There total 12 articles about [(5R)-5-methylundecyl](phenyl)sulfone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methylphenylsulfonate;
With
n-butyllithium;
In
tetrahydrofuran; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; hexane;
at -40 ℃;
for 0.5h;
Inert atmosphere;
(4R)-1-iodo-4-methyldecane;
In
tetrahydrofuran; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; hexane;
at -40 - 20 ℃;
for 16h;
Inert atmosphere;
DOI:10.1039/c2ob06906g
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium iodide / acetone / 2 h / Inert atmosphere; Reflux
2.1: n-butyllithium / tetrahydrofuran; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; hexane / 0.5 h / -40 °C / Inert atmosphere
2.2: 16 h / -40 - 20 °C / Inert atmosphere
With
n-butyllithium; sodium iodide;
In
tetrahydrofuran; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; hexane; acetone;
DOI:10.1039/c2ob06906g
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: dmap / dichloromethane / 16 h / 20 °C / Inert atmosphere
2.1: sodium iodide / acetone / 2 h / Inert atmosphere; Reflux
3.1: n-butyllithium / tetrahydrofuran; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; hexane / 0.5 h / -40 °C / Inert atmosphere
3.2: 16 h / -40 - 20 °C / Inert atmosphere
With
dmap; n-butyllithium; sodium iodide;
In
tetrahydrofuran; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; hexane; dichloromethane; acetone;
DOI:10.1039/c2ob06906g
