10,12-dihydroxy-2-acetoxy-6-(tert-butyldimethylsiloxy)-3-((4'-methoxyphenyl)thio)-11-oxo-1,4,4a(R),5,5a(S),6(S),11,12a(S)-octahydronaphthacene

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Chemical Name:10,12-dihydroxy-2-acetoxy-6-(tert-butyldimethylsiloxy)-3-((4'-methoxyphenyl)thio)-11-oxo-1,4,4a(R*),5,5a(S*),6(S*),11,12a(S*)-octahydronaphthacene
CAS No.:86668-47-5
Molecular Formula:C₃₃H₄₀O₇SSi
Molecular Weight:608.828
Hs Code.:

Synonyms:10,12-dihydroxy-2-acetoxy-6-(tert-butyldimethylsiloxy)-3-((4'-methoxyphenyl)thio)-11-oxo-1,4,4a(R*),5,5a(S*),6(S*),11,12a(S*)-octahydronaphthacene

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Chemical Property of 10,12-dihydroxy-2-acetoxy-6-(tert-butyldimethylsiloxy)-3-((4'-methoxyphenyl)thio)-11-oxo-1,4,4a(R*),5,5a(S*),6(S*),11,12a(S*)-octahydronaphthacene

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Technology Process of 10,12-dihydroxy-2-acetoxy-6-(tert-butyldimethylsiloxy)-3-((4'-methoxyphenyl)thio)-11-oxo-1,4,4a(R*),5,5a(S*),6(S*),11,12a(S*)-octahydronaphthacene

There total 11 articles about 10,12-dihydroxy-2-acetoxy-6-(tert-butyldimethylsiloxy)-3-((4'-methoxyphenyl)thio)-11-oxo-1,4,4a(R*),5,5a(S*),6(S*),11,12a(S*)-octahydronaphthacene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 81418-10-2
10,11-dihydroxy-2-acetoxy-6-(tert-butyldimethylsiloxy)-3-((4'-methoxyphenyl)thio)-12-oxo-1,4,4a(R*),5,5a(S*),6(S*),11(R*),11a(R*),12,12a(S*)-decahydronaphthacene

: 86668-47-5
10,12-dihydroxy-2-acetoxy-6-(tert-butyldimethylsiloxy)-3-((4'-methoxyphenyl)thio)-11-oxo-1,4,4a(R*),5,5a(S*),6(S*),11,12a(S*)-octahydronaphthacene

Guidance literature:: With manganese(IV) oxide; In acetone; at 25 ℃; for 0.75h;
DOI:10.1021/jo00167a020

Reference yield:

: 86668-63-5
8-hydroxy-1-acetoxy-1(R*),4,4a(S*),9a(S*)-tetrahydroanthraquinone

: 86668-47-5
10,12-dihydroxy-2-acetoxy-6-(tert-butyldimethylsiloxy)-3-((4'-methoxyphenyl)thio)-11-oxo-1,4,4a(R*),5,5a(S*),6(S*),11,12a(S*)-octahydronaphthacene

Guidance literature:: Multi-step reaction with 9 steps

1: NaBH₄ / toluene; methanol / 0.12 h / 5 °C

2: 84 percent / 1-hydroxybenzotriazole, Et₃N / acetonitrile / 0.5 h / 65 °C / var. silyl transfer agents, without Et₃N, var. solv., var. temp., var. time

3: 59 percent / LiBH₄ / tetrahydrofuran / 48 h / 0 °C

4: 86 percent / imidazole / dimethylformamide / 6 h / 50 °C

5: 91 percent / diisobutylaluminum hydride / toluene; hexane / 0.5 h / -62 °C

6: 82 percent / Ac₂O / toluene / 20 h / 25 °C

7: 83 percent / 1 M BCl₃ / CH₂Cl₂ / 1.) 1 h, -15 deg C, 2.) 2 h, 0 deg C

8: 88 percent / pyridinium poly(hydrogen fluoride) / tetrahydrofuran; pyridine / 1.5 h / 25 °C

9: 76 percent / MnO₂ / acetone / 0.75 h / 25 °C

With 1H-imidazole; manganese(IV) oxide; sodium tetrahydroborate; lithium borohydride; acetic anhydride; boron trichloride; diisobutylaluminium hydride; benzotriazol-1-ol; pyridine hydrogenfluoride; triethylamine; In tetrahydrofuran; pyridine; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;
DOI:10.1021/jo00167a020

Reference yield:

: 65174-13-2
2-acetoxy-3-(4'-methoxyphenylthio)-1,3-butadiene

: 86668-47-5
10,12-dihydroxy-2-acetoxy-6-(tert-butyldimethylsiloxy)-3-((4'-methoxyphenyl)thio)-11-oxo-1,4,4a(R*),5,5a(S*),6(S*),11,12a(S*)-octahydronaphthacene

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / 1 M BCl₃ / CH₂Cl₂ / 1.) 1 h, -15 deg C, 2.) 2 h, 0 deg C

2: 88 percent / pyridinium poly(hydrogen fluoride) / tetrahydrofuran; pyridine / 1.5 h / 25 °C

3: 76 percent / MnO₂ / acetone / 0.75 h / 25 °C

With manganese(IV) oxide; boron trichloride; pyridine hydrogenfluoride; In tetrahydrofuran; pyridine; dichloromethane; acetone;
DOI:10.1021/jo00167a020