1-(1-(4-chloro-3-methoxyphenyl)-4-methylpiperidin-4-yl)-2-(4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)ethanol

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Chemical Name:1-(1-(4-chloro-3-methoxyphenyl)-4-methylpiperidin-4-yl)-2-(4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)ethanol
CAS No.:1018325-40-0
Molecular Formula:C₂₀H₂₄Cl₂F₃N₃O₂
Molecular Weight:466.331
Hs Code.:

Synonyms:1-(1-(4-chloro-3-methoxyphenyl)-4-methylpiperidin-4-yl)-2-(4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)ethanol

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Chemical Property of 1-(1-(4-chloro-3-methoxyphenyl)-4-methylpiperidin-4-yl)-2-(4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)ethanol

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Technology Process of 1-(1-(4-chloro-3-methoxyphenyl)-4-methylpiperidin-4-yl)-2-(4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)ethanol

There total 4 articles about 1-(1-(4-chloro-3-methoxyphenyl)-4-methylpiperidin-4-yl)-2-(4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 235106-12-4
4-chloro-3-methyl-5-(trifluoromethyl)-1H-pyrazole

: C₁₅H₂₀ClNO₂

: 1018325-40-0
1-(1-(4-chloro-3-methoxyphenyl)-4-methylpiperidin-4-yl)-2-(4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)ethanol

Guidance literature:: In N,N-dimethyl-formamide; at 150 ℃; for 14h;

Reference yield:

: 1018325-42-2
methyl 1-(4-chloro-3-methoxyphenyl)piperidine-4-carboxylate

: 1018325-40-0
1-(1-(4-chloro-3-methoxyphenyl)-4-methylpiperidin-4-yl)-2-(4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)ethanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 1.5 h / -70 °C

1.2: 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 1 h / 20 °C

2.2: 0.5 h

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -70 °C

3.2: 0.5 h / -70 °C

4.1: methyllithium / tetrahydrofuran; diethyl ether / 1.5 h / -78 °C

5.1: sodium hydride / tetrahydrofuran / 1 h / 20 °C / Heating / reflux

5.2: 0.17 h / 80 °C

6.1: N,N-dimethyl-formamide / 14 h / 150 °C

With lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; methyllithium; sodium hydride; dimethyl sulfoxide; diisopropylamine; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1018325-46-6
(1-(4-chloro-3-methoxyphenyl)-4-methylpiperidin-4-yl)methanol

: 1018325-40-0
1-(1-(4-chloro-3-methoxyphenyl)-4-methylpiperidin-4-yl)-2-(4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)ethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -70 °C

1.2: 0.5 h / -70 °C

2.1: methyllithium / tetrahydrofuran; diethyl ether / 1.5 h / -78 °C

3.1: sodium hydride / tetrahydrofuran / 1 h / 20 °C / Heating / reflux

3.2: 0.17 h / 80 °C

4.1: N,N-dimethyl-formamide / 14 h / 150 °C

With oxalyl dichloride; methyllithium; sodium hydride; dimethyl sulfoxide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;