(S)-N-((3-(3-fluoro-4-(4-(3-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-7-yloxy)propyl)piperazin-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide hydrochloride

Base Information

Chemical Name:(S)-N-((3-(3-fluoro-4-(4-(3-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-7-yloxy)propyl)piperazin-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide hydrochloride
CAS No.:1282094-22-7
Molecular Formula:C₂₆H₃₂BFN₄O₆
Molecular Weight:526.373
Hs Code.:

(S)-N-((3-(3-fluoro-4-(4-(3-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-7-yloxy)propyl)piperazin-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide hydrochloride

Synonyms:(S)-N-((3-(3-fluoro-4-(4-(3-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-7-yloxy)propyl)piperazin-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide hydrochloride

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Chemical Property of (S)-N-((3-(3-fluoro-4-(4-(3-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-7-yloxy)propyl)piperazin-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide hydrochloride

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Technology Process of (S)-N-((3-(3-fluoro-4-(4-(3-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-7-yloxy)propyl)piperazin-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide hydrochloride

There total 11 articles about (S)-N-((3-(3-fluoro-4-(4-(3-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-7-yloxy)propyl)piperazin-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 7-(3-bromo-propoxy)-3H-benzo[c][1,2]oxaborol-1-ol

: 154590-66-6,154590-43-9
(S)-N-[[3-[3-fluoro-4-(1-piperazinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide

: 1282094-22-7
(S)-N-((3-(3-fluoro-4-(4-(3-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-7-yloxy)propyl)piperazin-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide hydrochloride

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 - 40 ℃;

Reference yield:

: 154590-34-8
4-(2-fluoro-4-nitrophenyl)-piperazine-1-carboxylic acid tert butyl ester

: 1282094-22-7
(S)-N-((3-(3-fluoro-4-(4-(3-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-7-yloxy)propyl)piperazin-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide hydrochloride

Guidance literature:: Multi-step reaction with 10 steps

1.1: hydrogen / Raney Ni / dichloromethane; methanol / 1 h / 2585.81 Torr

2.1: hydrogenchloride; water / 1,4-dioxane

3.1: sodium carbonate / water; acetone / 5 °C

4.1: n-butyllithium / hexane; tetrahydrofuran / -78 °C

4.2: -60 - 20 °C

5.1: pyridine / 5 - 20 °C

6.1: sodium azide / N,N-dimethyl-formamide / 24 h / 65 °C

7.1: triphenylphosphine; water / tetrahydrofuran / Reflux

8.1: pyridine / dichloromethane / 5 - 20 °C

9.1: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 12.5 h

10.1: triethylamine / N,N-dimethyl-formamide / 20 - 40 °C

With pyridine; hydrogenchloride; n-butyllithium; sodium azide; water; hydrogen; sodium carbonate; triethylamine; triphenylphosphine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 154590-35-9
tert-butyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate

: 1282094-22-7
(S)-N-((3-(3-fluoro-4-(4-(3-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-7-yloxy)propyl)piperazin-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1.1: hydrogenchloride; water / 1,4-dioxane

2.1: sodium carbonate / water; acetone / 5 °C

3.1: n-butyllithium / hexane; tetrahydrofuran / -78 °C

3.2: -60 - 20 °C

4.1: pyridine / 5 - 20 °C

5.1: sodium azide / N,N-dimethyl-formamide / 24 h / 65 °C

6.1: triphenylphosphine; water / tetrahydrofuran / Reflux

7.1: pyridine / dichloromethane / 5 - 20 °C

8.1: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 12.5 h

9.1: triethylamine / N,N-dimethyl-formamide / 20 - 40 °C

With pyridine; hydrogenchloride; n-butyllithium; sodium azide; water; hydrogen; sodium carbonate; triethylamine; triphenylphosphine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetone;