methyl 4-(2-{1-benzyl-5-chloro-2-[(E)-2-nitrovinyl]-1H-indol-3-yl}ethoxy)benzoate

Base Information

Chemical Name:methyl 4-(2-{1-benzyl-5-chloro-2-[(E)-2-nitrovinyl]-1H-indol-3-yl}ethoxy)benzoate
CAS No.:934284-95-4
Molecular Formula:C₂₇H₂₃ClN₂O₅
Molecular Weight:490.943
Hs Code.:

Synonyms:methyl 4-(2-{1-benzyl-5-chloro-2-[(E)-2-nitrovinyl]-1H-indol-3-yl}ethoxy)benzoate

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Chemical Property of methyl 4-(2-{1-benzyl-5-chloro-2-[(E)-2-nitrovinyl]-1H-indol-3-yl}ethoxy)benzoate

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Technology Process of methyl 4-(2-{1-benzyl-5-chloro-2-[(E)-2-nitrovinyl]-1H-indol-3-yl}ethoxy)benzoate

There total 4 articles about methyl 4-(2-{1-benzyl-5-chloro-2-[(E)-2-nitrovinyl]-1H-indol-3-yl}ethoxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 934284-64-7
methyl 4-[2-(1-benzyl-5-chloro-2-formyl-1H-indol-3-yl)ethoxy]benzoate

: 75-52-5
nitromethane

: 934284-95-4
methyl 4-(2-{1-benzyl-5-chloro-2-[(E)-2-nitrovinyl]-1H-indol-3-yl}ethoxy)benzoate

Guidance literature:: With ammonium acetate; for 3h; Heating;
DOI:10.1021/jm061131z

Reference yield:

: 479422-23-6
methyl 4-[2-(5-chloro-2-methyl-1H-indol-3-yl)ethoxy]benzoate

: 934284-95-4
methyl 4-(2-{1-benzyl-5-chloro-2-[(E)-2-nitrovinyl]-1H-indol-3-yl}ethoxy)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: NBS; benzoyl peroxide / CCl₄ / 2 h / -78 °C

2.1: 1.0 g / Ag₂CO₃; H₂O / acetone / 16 h

3.1: NaH / dimethylformamide / 0.17 h / 0 °C

3.2: 16 percent / dimethylformamide / 2 h

4.1: 82 percent / NH₄OAc / 3 h / Heating

With N-Bromosuccinimide; ammonium acetate; water; sodium hydride; silver carbonate; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide; acetone; 4.1: Henry reaction;
DOI:10.1021/jm061131z

Reference yield:

: C₁₉H₁₆Br₂ClNO₃

: 934284-95-4
methyl 4-(2-{1-benzyl-5-chloro-2-[(E)-2-nitrovinyl]-1H-indol-3-yl}ethoxy)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1.0 g / Ag₂CO₃; H₂O / acetone / 16 h

2.1: NaH / dimethylformamide / 0.17 h / 0 °C

2.2: 16 percent / dimethylformamide / 2 h

3.1: 82 percent / NH₄OAc / 3 h / Heating

With ammonium acetate; water; sodium hydride; silver carbonate; In N,N-dimethyl-formamide; acetone; 3.1: Henry reaction;
DOI:10.1021/jm061131z