3-ethyl-5-[5-hydroxy-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazol-3-yl]-1H-indazol-6-ol

Base Information

Chemical Name:3-ethyl-5-[5-hydroxy-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazol-3-yl]-1H-indazol-6-ol
CAS No.:1464138-59-7
Molecular Formula:C₂₁H₂₂N₆O₃
Molecular Weight:406.444
Hs Code.:

Synonyms:3-ethyl-5-[5-hydroxy-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazol-3-yl]-1H-indazol-6-ol

Suppliers and Price of 3-ethyl-5-[5-hydroxy-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazol-3-yl]-1H-indazol-6-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-ethyl-5-[5-hydroxy-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazol-3-yl]-1H-indazol-6-ol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-ethyl-5-[5-hydroxy-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazol-3-yl]-1H-indazol-6-ol

There total 10 articles about 3-ethyl-5-[5-hydroxy-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazol-3-yl]-1H-indazol-6-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-(6-benzyloxy-3-ethyl-1H-indazol-5-yl)-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]-triazol-3-ol

: 1464138-59-7
3-ethyl-5-[5-hydroxy-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazol-3-yl]-1H-indazol-6-ol

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol;

Reference yield:

: 1464139-74-9
6-benzyloxy-3-ethyl-1H-indazole-5-carboxylic acid methyl ester

: 1464138-59-7
3-ethyl-5-[5-hydroxy-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazol-3-yl]-1H-indazol-6-ol

Guidance literature:: Multi-step reaction with 5 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere

2: Dess-Martin periodane / dichloromethane / 0.25 h

3: acetic acid / ethanol / 1 h / 60 °C

4: sodium hydroxide; potassium hexacyanoferrate(III) / ethanol / 8 h / 80 °C

5: palladium 10% on activated carbon; hydrogen / methanol

With lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; Dess-Martin periodane; acetic acid; sodium hydroxide; potassium hexacyanoferrate(III); In tetrahydrofuran; methanol; ethanol; dichloromethane;

Reference yield:

: 1464139-82-9
(6-benzyloxy-3-ethyl-1H-indazole-5-yl)carboxaldehyde

: 1464138-59-7
3-ethyl-5-[5-hydroxy-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazol-3-yl]-1H-indazol-6-ol

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / ethanol / 1 h / 60 °C

2: sodium hydroxide; potassium hexacyanoferrate(III) / ethanol / 8 h / 80 °C

3: palladium 10% on activated carbon; hydrogen / methanol

With palladium 10% on activated carbon; hydrogen; acetic acid; sodium hydroxide; potassium hexacyanoferrate(III); In methanol; ethanol;