Technology Process of benzyl (1S,3R)-2,2-dimethyl-3-(piperidine-1-carbonyl)cyclobutylcarbamate
There total 5 articles about benzyl (1S,3R)-2,2-dimethyl-3-(piperidine-1-carbonyl)cyclobutylcarbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(1R,3S)-3-(((benzyloxy)carbonyl)amino)-2,2-dimethylcyclobutan-1-carboxylic acid;
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane;
at 0 ℃;
piperidine;
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 12h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium periodate; water / ruthenium(III) trichloride hydrate / tetrachloromethane; acetonitrile / 12 h / 0 - 20 °C
2.1: chloroformic acid ethyl ester; triethylamine / acetone / 0 °C
2.2: 1.5 h / 0 - 20 °C
3.1: toluene / 4 h / 20 °C / Reflux
4.1: water; sodium hypobromide / 1,4-dioxane / 5 h / -5 °C
4.2: pH 2 - 3
5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0 °C
5.2: 12 h / 20 °C
With
sodium periodate; sodium hypobromide; water; chloroformic acid ethyl ester; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
ruthenium(III) trichloride hydrate;
In
1,4-dioxane; tetrachloromethane; dichloromethane; acetone; toluene; acetonitrile;
3.1: Curtius Rearrangement;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: chloroformic acid ethyl ester; triethylamine / acetone / 0 °C
1.2: 1.5 h / 0 - 20 °C
2.1: toluene / 4 h / 20 °C / Reflux
3.1: water; sodium hypobromide / 1,4-dioxane / 5 h / -5 °C
3.2: pH 2 - 3
4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0 °C
4.2: 12 h / 20 °C
With
sodium hypobromide; water; chloroformic acid ethyl ester; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
1,4-dioxane; dichloromethane; acetone; toluene;
2.1: Curtius Rearrangement;
