N-cyclopropyl-4-{6-[(1RS)-1-(3-fluoro-4-methoxyphenyl)-1-hydroxyethyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-(hydroxymethyl)benzamide

Base Information

Chemical Name:N-cyclopropyl-4-{6-[(1RS)-1-(3-fluoro-4-methoxyphenyl)-1-hydroxyethyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-(hydroxymethyl)benzamide
CAS No.:1401450-92-7
Molecular Formula:C₃₀H₃₀F₄N₄O₄
Molecular Weight:586.586
Hs Code.:

N-cyclopropyl-4-{6-[(1RS)-1-(3-fluoro-4-methoxyphenyl)-1-hydroxyethyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-(hydroxymethyl)benzamide

Synonyms:N-cyclopropyl-4-{6-[(1RS)-1-(3-fluoro-4-methoxyphenyl)-1-hydroxyethyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-(hydroxymethyl)benzamide

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Chemical Property of N-cyclopropyl-4-{6-[(1RS)-1-(3-fluoro-4-methoxyphenyl)-1-hydroxyethyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-(hydroxymethyl)benzamide

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Technology Process of N-cyclopropyl-4-{6-[(1RS)-1-(3-fluoro-4-methoxyphenyl)-1-hydroxyethyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-(hydroxymethyl)benzamide

There total 11 articles about N-cyclopropyl-4-{6-[(1RS)-1-(3-fluoro-4-methoxyphenyl)-1-hydroxyethyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-(hydroxymethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1401450-86-9
N-cyclopropyl-4-{6-(3-fluoro-4-methoxybenzoyl)-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide

: 917-54-4
methyllithium

: 1401450-91-6
N-cyclopropyl-4-{6-[(1RS)-1-(3-fluoro-4-methoxyphenyl)-1-hydroxyethyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide

: 1401450-92-7
N-cyclopropyl-4-{6-[(1RS)-1-(3-fluoro-4-methoxyphenyl)-1-hydroxyethyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-(hydroxymethyl)benzamide

Guidance literature:: N-cyclopropyl-4-{6-(3-fluoro-4-methoxybenzoyl)-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide; methyllithium; In tetrahydrofuran; diethyl ether; at 3 ℃; for 1h;

With water; In tetrahydrofuran; diethyl ether;

Reference yield:

: 606-22-4
2,6-dinitroaniline

: 1401450-91-6
N-cyclopropyl-4-{6-[(1RS)-1-(3-fluoro-4-methoxyphenyl)-1-hydroxyethyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide

: 1401450-92-7
N-cyclopropyl-4-{6-[(1RS)-1-(3-fluoro-4-methoxyphenyl)-1-hydroxyethyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-(hydroxymethyl)benzamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: bromine; acetic acid

2.1: hydrogenchloride; tin(II) chloride dihdyrate / water / -20 - 20 °C

2.2: pH 10

3.1: hydrogenchloride / 20 °C / Reflux

3.2: pH 8

4.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 23 °C

4.2: 3 °C

5.1: pyridine N-oxide; pyridine; copper diacetate / dichloromethane / 60 h / 23 °C

6.1: N-ethyl-N,N-diisopropylamine; palladium diacetate; catacxium A / toluene / 100 °C / 10501.1 Torr

7.1: water; lithium hydroxide / tetrahydrofuran; methanol / 23 °C

8.1: dmap; HATU / N,N-dimethyl-formamide / 23 °C

9.1: diethyl ether; tetrahydrofuran / 1 h / 3 °C

With pyridine; pyridine N-oxide; hydrogenchloride; dmap; tin(II) chloride dihdyrate; water; bromine; copper diacetate; palladium diacetate; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; catacxium A; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1360899-50-8
6-bromo-1H-1,3-benzodiazol-4-amine

: 1401450-91-6
N-cyclopropyl-4-{6-[(1RS)-1-(3-fluoro-4-methoxyphenyl)-1-hydroxyethyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide

: 1401450-92-7
N-cyclopropyl-4-{6-[(1RS)-1-(3-fluoro-4-methoxyphenyl)-1-hydroxyethyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-(hydroxymethyl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 23 °C

1.2: 3 °C

2.1: pyridine N-oxide; pyridine; copper diacetate / dichloromethane / 60 h / 23 °C

3.1: N-ethyl-N,N-diisopropylamine; palladium diacetate; catacxium A / toluene / 100 °C / 10501.1 Torr

4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 23 °C

5.1: dmap; HATU / N,N-dimethyl-formamide / 23 °C

6.1: diethyl ether; tetrahydrofuran / 1 h / 3 °C

With pyridine; pyridine N-oxide; dmap; water; copper diacetate; palladium diacetate; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; catacxium A; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene;