{1-[2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-5-hydroxy-pentyl}-methyl-carbamic acid tert-butyl ester

Base Information

Chemical Name:{1-[2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-5-hydroxy-pentyl}-methyl-carbamic acid tert-butyl ester
CAS No.:423763-85-3
Molecular Formula:C₂₅H₄₅NO₄Si
Molecular Weight:451.722
Hs Code.:

{1-[2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-5-hydroxy-pentyl}-methyl-carbamic acid <i>tert</i>-butyl ester

Synonyms:{1-[2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-5-hydroxy-pentyl}-methyl-carbamic acid tert-butyl ester

Suppliers and Price of {1-[2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-5-hydroxy-pentyl}-methyl-carbamic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of {1-[2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-5-hydroxy-pentyl}-methyl-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of {1-[2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-5-hydroxy-pentyl}-methyl-carbamic acid tert-butyl ester

There total 12 articles about {1-[2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-5-hydroxy-pentyl}-methyl-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 423763-84-2
{1-[2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-pent-4-enyl}-methyl-carbamic acid tert-butyl ester

: 423763-85-3
{1-[2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-5-hydroxy-pentyl}-methyl-carbamic acid tert-butyl ester

Guidance literature:: {1-[2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-pent-4-enyl}-methyl-carbamic acid tert-butyl ester; With bis(cyclohexanyl)borane; In dichloromethane; at 0 - 20 ℃; for 6h;

With sodium hydroxide; dihydrogen peroxide; In water; at 0 - 20 ℃; for 1h;
DOI:10.1016/S0040-4039(01)02105-0

Reference yield:

: 6249-80-5
1-phenylbut-3-en-1-one

: 423763-85-3
{1-[2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-5-hydroxy-pentyl}-methyl-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: 84 percent / (+)-Ipc₂BCl / tetrahydrofuran / 12 h / -35 °C

2.1: 90 percent / n-BuLi / diethyl ether; tetrahydrofuran / 2.5 h / -78 - 20 °C

3.1: 85 percent / IBr / toluene; CH₂Cl₂ / 1 h / -85 °C

4.1: 96 percent / K₂CO₃ / methanol / 2 h / 20 °C

5.1: 96 percent / Et₃N; DMAP / dimethylformamide / 3 h / 20 °C

6.1: 91 percent / CuI / diethyl ether / 0.5 h / -40 °C

7.1: 88 percent / Et₃N / CH₂Cl₂ / 0.17 h / 0 °C

8.1: 83 percent / dimethylformamide; H₂O / 20 h / 60 °C

9.1: 95 percent / Et₃N / CH₂Cl₂ / 6 h / 20 °C

10.1: Cy₂BH / CH₂Cl₂ / 6 h / 0 - 20 °C

10.2: 90 percent / H₂O₂; NaOH / H₂O / 1 h / 0 - 20 °C

With dmap; copper(l) iodide; n-butyllithium; (+)-β-chlorodiisopinocampheylborane; bis(cyclohexanyl)borane; iodine(I) bromide; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4039(01)02105-0

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 423763-85-3
{1-[2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-5-hydroxy-pentyl}-methyl-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 95 percent / Et₃N / CH₂Cl₂ / 6 h / 20 °C

2.1: Cy₂BH / CH₂Cl₂ / 6 h / 0 - 20 °C

2.2: 90 percent / H₂O₂; NaOH / H₂O / 1 h / 0 - 20 °C

With bis(cyclohexanyl)borane; triethylamine; In dichloromethane;
DOI:10.1016/S0040-4039(01)02105-0