{1-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperidin-4-yl}-(1-methyl-1H-benzoimidazol-2-yl)-amine

Base Information

Chemical Name:{1-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperidin-4-yl}-(1-methyl-1H-benzoimidazol-2-yl)-amine
CAS No.:98244-76-9
Molecular Formula:C₂₉H₃₂F₂N₄
Molecular Weight:474.597
Hs Code.:

Synonyms:{1-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperidin-4-yl}-(1-methyl-1H-benzoimidazol-2-yl)-amine

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Chemical Property of {1-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperidin-4-yl}-(1-methyl-1H-benzoimidazol-2-yl)-amine

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Technology Process of {1-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperidin-4-yl}-(1-methyl-1H-benzoimidazol-2-yl)-amine

There total 6 articles about {1-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperidin-4-yl}-(1-methyl-1H-benzoimidazol-2-yl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75970-51-3
1-methyl-N-(4-piperidinyl)-1H-benzimidazol-2-amine dihydrobromide

: 98244-76-9
{1-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperidin-4-yl}-(1-methyl-1H-benzoimidazol-2-yl)-amine

Guidance literature:: With sodium carbonate; In N,N-dimethyl-formamide; at 90 ℃;
DOI:10.1021/jm00150a029

Reference yield:

: 58859-46-4
ethyl 4-aminopiperidine-1-carboxylate

: 98244-76-9
{1-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperidin-4-yl}-(1-methyl-1H-benzoimidazol-2-yl)-amine

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) sodium hydroxide, 2.) ethyl chloroformate / 1.) water, 10 deg C, 30 min, 2.) water, 60 deg C, 2 h

2: 100 percent / ethanol / Ambient temperature

3: 55.5 percent / yellow HgO, sulfur / ethanol / 2 h / Heating

4: 66 percent / sodium carbonate / dimethylformamide / 70 °C

5: 89 percent / 48 percent hydrobromic acid / 3 h / Heating

6: Na₂CO₃ / dimethylformamide / 90 °C

With sodium hydroxide; hydrogen bromide; chloroformic acid ethyl ester; sodium carbonate; sulfur; mercury(II) oxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00150a029

Reference yield:

: 73733-70-7
ethyl 4-isothiocyanato-1-piperidinecarboxylate

: 98244-76-9
{1-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperidin-4-yl}-(1-methyl-1H-benzoimidazol-2-yl)-amine

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / ethanol / Ambient temperature

2: 55.5 percent / yellow HgO, sulfur / ethanol / 2 h / Heating

3: 66 percent / sodium carbonate / dimethylformamide / 70 °C

4: 89 percent / 48 percent hydrobromic acid / 3 h / Heating

5: Na₂CO₃ / dimethylformamide / 90 °C

With hydrogen bromide; sodium carbonate; sulfur; mercury(II) oxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00150a029